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PRJNA285502 SRP061957

FMT for ulcerative colitis in adults, intervention study

Fecal microbiota transplantation (FMT) for ulcerative colitis

41 fecal samples from adults with ulcerative colitis receiving a single colonoscopic fecal microbiota transplantation, in an intervention study assessing donor microbiota engraftment. machine-written summary

41 samples · 52 runs · US · Adult · 2017 · 4.25 Gbp / sample

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Sources
✓Sequence archive 41○Abstract / description✓Full text 41○Supplementary tables✓External resources 123–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive41 sample values (subject id)
○ Abstract / descriptionread; no usable statement
✓ Full text41 sample values (collection date) · PMC12180181, PMC4544847
○ Supplementary tablesfiles read; no table could be matched to the samples
✓ External resources123 sample values (country, health condition, health condition detail) · from GMrepo v3
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Interventions

intervention — arms not resolved

Faecal microbiota transplantation design single_arm_before_after · population ulcerative_colitis · Single colonoscopic FMT administration in UC patients

“received a single colonoscopic administration of FMT” — abstract:26288277 (study level; per-sample arms are in the intervention column below)

Samples at a glance
1 country
Age
adult41
Condition
ulcerative_colitis41
Country
US41
Body site
primary41
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)this project, 0.1–0.3 Gbp: 1 samplesall projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 2 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 8 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 29 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 1 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 4.25 Gbp per sample0130Gbp
Sampling design and relatedness

longitudinal — not resolvedFMT donor → recipient — not resolvedhouseholds — not resolvedparent–child — not resolvedpartners / couples — not resolved

11 of 12 people sampled more than once (40 samples; median 5, up to 5 per person). Schedule stated by the source: “stool at baseline, week 4, 1 month, 2-3 months, and 3 months after FMT”; stated follow-up 3 mo.

6 donor and 6 recipient codes; donors chosen by recipients (husbands, father, brother-in-law, roommate, ex-boyfriend), 4/7 cohabiting; code-to-pair map unpublished.

How longitudinal and relatedness information is derived

Community composition
Faecalibacterium 8.0%Phocaeicola 7.2%Blautia_A 6.6%Roseburia 6.3%Bacteroides 5.4%Prevotella 3.9%Bifidobacterium 3.5%Lachnospira 3.2%Collinsella 2.8%Mediterraneibacter 2.4%Anaerostipes 2.4%Dorea_A 1.8%not assigned to a genus 9.1%other genera 37.4%

Genera, mean relative abundance over 39 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category41 100%
country41 100%41
health_condition41 100%41
subject_id41 100%41
collection_date41 100%41
health_condition_detail41 100%41
Papers (2)
  • Low Level Engraftment and Improvement following a Single Colonoscopic Administration of Fecal Microbiota to Patients with Ulcerative Colitis. 2015 PMID 26288277 PMC4544847 own_data
  • Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantation. 2025 PMID 40542451 PMC12180181 unsure
Details
Archive description

Clinical study of Fecal microbiota transplantation (FMT) therapy for ulcerative colitis

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.title · “Fecal microbiota transplantation (FMT)”
  • body site study.description · “Clinical study of Fecal microbiota transplantation (FMT)”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN03955539collection_date2012-10/2013-05R30.70paper.fulltext.methodsSubjects were enrolled between October 2012 and May of 2013
SAMN03955539countryUSR20.75external.gmrepo sourcecountry: United States of America
SAMN03955539health_conditionulcerative_colitisR20.75external.gmrepo sourcephenotype: Colitis, Ulcerative
SAMN03955539health_condition_detailColitis, UlcerativeR20.75external.gmrepo sourcephenotype: Colitis, Ulcerative
SAMN03955539subject_id202R10.70sample.name_rule:titleUWIBD01D202B1
Sequencing

52 runs over 41 samples · mean 3.48 Gbp per run (median 3.02 Gbp, total 181.08 Gbp; 52 runs with a base count) · layout PAIRED 52 · platform ILLUMINA 52 · models Illumina HiSeq 2000 (33), Illumina MiSeq (19) · 92% of runs with a Sandpiper profile · first public 2017-11-08

Authors (24)

Damman CJ first · Brittnacher MJ · Westerhoff M · Hayden HS · Radey M · Hager KR · Marquis SR · Miller SI · Zisman TL last · Hu H first · Tan Y · Li C · Chen J · Kou Y · Xu ZZ · Liu YY · Dai L last · Ji S first · Ahmad F · Peng B · Yang Y · Su M · Zhao X · Vatanen T last

Downloads

PRJNA285502.csv.gz (1.9 KB) · parquet (70.5 KB) — all 41 samples, every field with route and confidence · PRJNA285502_determinations.csv.gz (2.3 KB) — 205 evidence rows

Samples (41 · every field this project has values for · hover a cell for its source)
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