Gut microbiome in pulmonary TB patients, New Delhi, India
Case-control study of 24 gut microbiome samples from New Delhi, India, comparing pulmonary tuberculosis patients undergoing antitubercular treatment with healthy controls. machine-written summary
24 samples · 24 runs · IN · Age unknown · 2018 · 8.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 222 sample values (antibiotic exposure, collection date, country, health condition, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 24 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC12614512, PMC8497558 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Antibiotic given as the study intervention (incl. eradication therapy design observational_with_procedure · population other_infection · Anti-tubercular therapy in pulmonary TB patients
“alterations in Gut microbiota due to pulmonary tuberculosis and anti-TB treatment” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
6 of 6 people sampled more than once (18 samples; median 3, up to 3 per person) · follow-up median 31 d (max 32 d) · median interval between samples 15 d (time from collection dates). Schedule stated by the source: “Patients sampled at Zero Day, Week Treatment, and Month Treatment during antitubercular therapy; controls sampled once.” (time origin: intervention_start).
Each row is one person (6 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 20 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 24 | 100% | 24 | |||
| health_condition | 24 | 100% | 24 | |||
| subject_id | 18 | 75% | 18 | |||
| collection_date | 24 | 100% | 24 | |||
| detailed_location | 24 | 100% | ||||
| health_condition_detail | 24 | 100% | 24 | |||
| latitude | 24 | 100% | 24 | |||
| location_locality | 24 | 100% | 24 | |||
| location_region | 24 | 100% | 24 | |||
| longitude | 24 | 100% | 24 | |||
| timepoint_label | 24 | 100% | 24 | |||
| antibiotic_exposure | 12 | 50% | 12 |
- Exploring gut microbiota and its predicted functions in pulmonary tuberculosis: A multi-regional study using public 16S datasets. 2025 PMID 41231796 PMC12614512 own_data
- Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth-gut axis. 2021 PMID 34620880 PMC8497558 unsure
Archive description
To study the alterations in Gut microbiota due to pulmonary tuberculosis and anti-TB treatment in patients and its comparison with Healthy controls.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “Gut microbiome of TB patients”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN05437189 | antibiotic_exposure | yes | R1 | 0.70 | sample.name_rule:alias | ABW |
| SAMN05437187 | collection_date | 2013-07-10 | R1 | 0.90 | biosample.attribute:collection_date | 2013-07-10 |
| SAMN05437187 | country | IN | R1 | 0.90 | sample.attr.geo_loc_name | India:New Delhi |
| SAMN05437187 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | ABC |
| SAMN05437187 | health_condition_detail | mixed_case_control: TB patients and healthy controls sampled together | R4 | 0.50 | study.description | patients and its comparison with Healthy controls |
| SAMN05437187 | latitude | 28.7886 | R1 | 0.90 | biosample.attribute:lat_lon | 28.7886 N 77.1412 E |
| SAMN05437187 | location_locality | New Delhi | R1 | 0.85 | biosample.attribute:geo_loc_name | India:New Delhi |
| SAMN05437187 | location_region | Delhi | R1 | 0.85 | biosample.attribute:geo_loc_name | India:New Delhi |
| SAMN05437187 | longitude | 77.1412 | R1 | 0.90 | biosample.attribute:lat_lon | 28.7886 N 77.1412 E |
| SAMN05437188 | subject_id | Patient AB | R1 | 0.70 | biosample.attribute:Type | Type: Zero Day Patient AB; alias: ABZ |
| SAMN05437187 | timepoint_label | Control | R1 | 0.70 | sample.name_rule:alias | ABC |
| SAMN05437188 | timepoint_label | Zero Day | R1 | 0.70 | sample.name_rule:type | Zero Day Patient AB |
Sequencing
24 runs over 24 samples · mean 8.29 Gbp per run (median 8.14 Gbp, total 199.02 Gbp; 24 runs with a base count) · layout PAIRED 24 · platform ILLUMINA 24 · models Illumina HiSeq 2500 (24) · 83% of runs with a Sandpiper profile · first public 2018-01-01
Authors (17)
Prasoodanan P K V first · Sharma AK · Mahajan S · Dhakan DB · Maji A · Scaria J · Sharma VK last · Baral T first · Maile A · Adimurthy NH · Saravu K · Kudru CU · Singh J · Mukhopadhyay C · Rao M · Manu MK · Sekhar Miraj S last
Downloads
PRJNA331073.csv.gz (1.7 KB) · parquet (71.8 KB) — all 24 samples, every field with route and confidence · PRJNA331073_determinations.csv.gz (3.0 KB) — 246 evidence rows