Metformin effects on gut microbiota in T2D patients
2 samples from adults with newly diagnosed type 2 diabetes, studied in a randomized, placebo-controlled, double-blind trial comparing metformin and calorie restriction effects on gut microbiota composition and function. machine-written summary
873 samples · 880 runs · Adult · 2017 · 0.92 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ○ Sequence archive | records read; no usable sample values |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10769881, PMC11009399, PMC11170963, PMC11237675, PMC11401871, PMC13067670, PMC6736778, PMC7707550, PMC9867701 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “Samples collected before treatment (M0/P0), after two months (M2/P2), and after four months (M4/P4)” (time origin: treatment start); stated follow-up 4 mo.
Genera, mean relative abundance over 2 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 873 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% |
- Metabolic modelling of the human gut microbiome in type 2 diabetes patients in response to metformin treatment. 2023 PMID 36681701 PMC9867701 own_data
- Plasmid-encoded toxin defence mediates mutualistic microbial interactions. 2024 PMID 38151647 PMC10769881 own_data
- Metformin increases gut multidrug resistance genes in type 2 diabetes, potentially linked to Escherichia coli. 2024 PMID 39277620 PMC11401871 own_data
- Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy. 2019 PMID 31474368 PMC6736778 unsure
- Perturbation of the human gastrointestinal tract microbial ecosystem by oral drugs to treat chronic disease results in a spectrum of individual specific patterns of extinction and persistence of dominant microbial strains. 2020 PMID 33259474 PMC7707550 unsure
5 more
- Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases. 2024 PMID 38605009 PMC11009399
- Changes in the type 2 diabetes gut mycobiome associate with metformin treatment across populations. 2024 PMID 38767350 PMC11237675
- Deciphering unique and shared interactions between the human gut microbiota and oral antidiabetic drugs. 2024 PMID 38882498 PMC11170963
- Metagenome-assembled genomes from the gut microbiome of spontaneous diabetic macaques provide insights into microbes associated with type 2 diabetes mellitus. 2026 PMID 41781883 PMC13067670
- Plasmid dispersal and recombination across human gut microbiomes is neutral, but overpowered by inflammatory diseases 2023
Archive description
In this study, we performed a randomized, placebo-controlled, double-blind study in newly diagnosed T2D patients on a calorie-restricted diet and showed that metformin, but not calorie restriction, had rapid effects on the composition and function of the gut microbiota.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “human gut metagenome Metagenome”
- body site study.description · “function of the gut microbiota.”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Sequencing
880 runs over 873 samples · mean 1.79 Gbp per run (median 0.92 Gbp, total 1,573.51 Gbp; 880 runs with a base count) · layout PAIRED 880 · platform ILLUMINA 880 · models NextSeq 500 (880) · 30% of runs with a Sandpiper profile · first public 2017-05-22 – 2017-06-21
Authors (27)
Koo H first · Morrow CD last · Ezzamouri B first · Rosario D · Bidkhori G · Lee S · Uhlen M · Shoaie S last · Kim HB first · Cho YJ · Choi SS last · Xie Y first · Wang R · Liu X · Du Q · Mo S · Liu Q · Yang G · Fan Z · Li J last · Mizrahi I first · Zorea A · Pellow D · Levin L · Pilosof S · Friedman J · Shamir R last
Help complete this project
3 of the 4 core fields are below 50% coverage: country, health_condition, subject_id. Share metadata
Downloads
PRJNA361402.csv.gz (16.1 KB) · parquet (92.5 KB) — all 873 samples, every field with route and confidence · PRJNA361402_determinations.csv.gz (168 B) — 0 evidence rows