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PRJNA397664 SRP115082

Gut microbial autoantigen and colitis, Calgary, Canada

A GUT MICROBIAL AUTOANTIGEN SUPPRESSES COLITIS

46 gut microbiome samples from Calgary, Canada, studying a gut microbial autoantigen linked to diabetogenic autoreactivity and colitis suppression; 6 samples labeled healthy controls; design otherwise unspecified. machine-written summary

23 samples · 46 runs · CA · Age unknown · 2017 · 3.27 Gbp / sample

Sources
✓Sequence archive 227–Abstract / description–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive227 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude)
– Abstract / descriptionno abstract or project description
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
unknown23
Condition
ibd_unspecified8
type1_diabetes8
healthy_control6
Sex
female17
male6
Country
CA23
Body site
primary23
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)this project, 0.03–0.1 Gbp: 1 samplesall projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 2 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 3 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 17 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 4.36 Gbp per sample0130Gbp
Community composition
Bacteroides 8.4%Alistipes 6.7%Prevotella 6.2%Phocaeicola 4.8%Duncaniella 4.3%Amulumruptor 4.2%Lepagella 3.9%Muribaculum 2.6%Parabacteroides 2.5%Helicobacter_C 1.9%Faecalibacterium 1.7%Ruminococcoides 1.3%not assigned to a genus 6.3%other genera 45.3%

Genera, mean relative abundance over 37 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country23 100%23
health_condition22 96%22
subject_id22 96%22
collection_date23 100%23
detailed_location23 100%
latitude23 100%23
location_locality23 100%23
location_region23 100%23
longitude23 100%23
sex23 100%23
health_condition_detail22 96%22
Papers (1)
  • A Gut Microbial Mimic that Hijacks Diabetogenic Autoreactivity to Suppress Colitis. 2017 PMID 29053971 own_data
Details
Archive description

A GUT MICROBIAL AUTOANTIGEN MIMIC THAT HIJACKS DIABETOGENIC AUTOREACTIVITY TO SUPPRESS COLITIS

How this project entered the registry

Classified as human and non-human (mixed) gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.65. Assay shotgun_dna.

  • host run.scientific_name · “human gut metagenome”
  • host run.scientific_name · “mouse gut metagenome”
  • body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN07490693collection_date2017R10.90biosample.attribute:collection_date2017
SAMN07490693countryCAR10.90sample.attr.geo_loc_nameCanada: Calgary
SAMN07490694health_conditiontype1_diabetesR10.70sample.name_rule:aliasT1D-1
SAMN07490694health_condition_detailT1DR10.70sample.name_rule:aliasT1D-1
SAMN07490693latitude51.0486R10.90biosample.attribute:lat_lon51.0486 N 114.0708 W
SAMN07490693location_localityCalgaryR10.85biosample.attribute:geo_loc_nameCanada: Calgary
SAMN07490693location_regionAlbertaR10.60biosample.attribute:lat_lon51.0486 N 114.0708 W
SAMN07490693longitude-114.0708R10.90biosample.attribute:lat_lon51.0486 N 114.0708 W
SAMN07490693sexfemaleR10.85biosample.attribute:descriptionfemale
SAMN07490694subject_idT1D subject 1R10.85biosample.attribute:source_material_idT1D subject sample 1
Sequencing

46 runs over 23 samples · mean 3.45 Gbp per run (median 3.27 Gbp, total 158.77 Gbp; 46 runs with a base count) · layout PAIRED 46 · platform ILLUMINA 46 · models NextSeq 500 (46) · 80% of runs with a Sandpiper profile · first public 2017-08-11

Authors (0)

No author record.

Downloads

PRJNA397664.csv.gz (1.6 KB) · parquet (71.2 KB) — all 23 samples, every field with route and confidence · PRJNA397664_determinations.csv.gz (2.5 KB) — 227 evidence rows

Samples (23 · every field this project has values for · hover a cell for its source)
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