Lactobacillus in ulcerative colitis
Meta-analysis and murine model study of Lactobacillus paracasei WIS43 for ulcerative colitis treatment. One sample from Cork, Ireland; compared anti-inflammatory efficacy against commercial strain and mesalazine. machine-written summary
22 samples · 22 runs · Age unknown · 2020 · 4.43 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 38 sample values (health condition, health condition detail) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11740686, PMC12455517, PMC12900382, PMC13484702, PMC6967091, PMC7089947, PMC9614153 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
Genera, mean relative abundance over 1 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 0 | 0% | ||||
| health_condition | 19 | 86% | 19 | |||
| subject_id | 0 | 0% | ||||
| health_condition_detail | 19 | 86% | 19 |
- Piphillin predicts metagenomic composition and dynamics from DADA2-corrected 16S rDNA sequences. 2020 PMID 31952477 PMC6967091 own_data
- Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease. 2020 PMID 32251296 PMC7089947 own_data
- Strain level and comprehensive microbiome analysis in inflammatory bowel disease via multi-technology meta-analysis identifies key bacterial influencers of disease. 2022 PMID 36312950 PMC9614153 own_data
- Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease. 2025 PMID 39812341 PMC11740686 own_data
- Human DNA hijacking microbiota surveys: causes and consequences in colon related 16s rRNA amplicon sequencing. 2025 PMID 40994617 PMC12455517 own_data
2 more
- <i>Lactobacillus paracasei</i> WIS43 alleviates DSS-induced colitis by modulating gut microbiota and suppressing inflammation. 2025 PMID 41695140 PMC12900382
- Generative AI-augmented transcriptomic and microbiome analysis across inflammatory and fibrotic disease states in Crohn's disease. 2026 PMID 42614810 PMC13484702
Archive description
Multi omic study of mucosal microbiome
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.57. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.title · “Human gut metagenome”
- body site run.scientific_name · “human gut metagenome(22)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SRR9157875 | health_condition | ulcerative_colitis | R1 | 0.70 | sample.name_rule:library_name | library_name: UC9_Shotgun |
| SRR9157875 | health_condition_detail | ulcerative colitis (UC) | R1 | 0.70 | sample.name_rule:library_name | library_name: UC9_Shotgun |
Sequencing
22 runs over 22 samples · mean 4.32 Gbp per run (median 4.43 Gbp, total 95.01 Gbp; 22 runs with a base count) · layout PAIRED 22 · platform ILLUMINA 22 · models Illumina HiSeq 4000 (22) · 91% of runs with a Sandpiper profile · first public 2020-04-14
Authors (34)
Narayan NR first · Weinmaier T · Laserna-Mendieta EJ · Claesson MJ · Shanahan F · Dabbagh K · Iwai S · DeSantis TZ last · Ravichandar JD first · Rutherford E · Chow CT · Han A · Yamamoto ML · Narayan N · Kaplan GG · Beck PL · Di Gloria L first · Casbarra L · Bastiani M · Memoli G · Ramazzotti M last · Fu Y first · Chen S · Cui L · Cao Y · Dong Y · Duan Y · Wu C last · Philip D first · Santos D · Mondal S · Alomar H · Gkoutos G · Acharjee A last
Downloads
PRJNA398187.csv.gz (1.4 KB) · parquet (69.1 KB) — all 22 samples, every field with route and confidence · PRJNA398187_determinations.csv.gz (899 B) — 38 evidence rows