Microbiome in gestational diabetes vs healthy pregnancy
145 fecal samples from pregnant women in China, comparing 75 patients with gestational diabetes mellitus to 70 healthy pregnant controls, using a case-control design. machine-written summary
145 samples · 145 runs · CN · Adult · 2017 · 6.90 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,015 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude) |
| ✓ Abstract / description | 145 sample values (subject id) |
| ○ Full text | read; no usable statement or table · PMC10492300, PMC12867416 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 145 sample values (sex) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 129 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 145 | 100% | ||||
| country | 145 | 100% | 145 | |||
| health_condition | 145 | 100% | 145 | |||
| subject_id | 145 | 100% | 145 | |||
| collection_date | 145 | 100% | 145 | |||
| detailed_location | 145 | 100% | ||||
| health_condition_detail | 145 | 100% | 145 | |||
| latitude | 145 | 100% | 145 | |||
| location_region | 145 | 100% | 145 | |||
| longitude | 145 | 100% | 145 | |||
| sex | 145 | 100% | 145 |
- Oral probiotics increased the proportion of Treg, Tfr, and Breg cells to inhibit the inflammatory response and impede gestational diabetes mellitus. 2023 PMID 37684563 PMC10492300 own_data
- Dynamic involvement of the core gut microbiome XNP_Guild1 in the evolution of gestational diabetes mellitus. 2026 PMID 41620634 PMC12867416 own_data
- Clinical significance of the genetically variable landscape of the gut microbiome in patients with gestational diabetes mellitus patients. 2024 PMID 39347390 PMC11438002 unsure
Archive description
we examined the composition and function of the gut microbiota from 75 patients with GDM and 70 healthy pregnant women in China, and further explore their possible associations with DM gut microbiome.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
- body site study.title · “Metagenomic analysis of fecal microbiome from patients”
- body site study.description · “function of the gut microbiota from 75”
- life stage external_curation.infant_catalog · “infant triage reason_code age_maternal_only”
- life stage study.description · “and 70 healthy pregnant women in China, and”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN07612656 | collection_date | 2015-07-28 | R1 | 0.90 | biosample.attribute:collection_date | 2015-07-28 |
| SAMN07612656 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN07612656 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:title | Non-GDM01 |
| SAMN07612656 | health_condition_detail | Non-GDM | R1 | 0.70 | sample.name_rule:title | Non-GDM01 |
| SAMN07612656 | latitude | 39.9200 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.42 E |
| SAMN07612656 | location_region | Beijing | R1 | 0.60 | biosample.attribute:lat_lon | 39.92 N 116.42 E |
| SAMN07612656 | longitude | 116.4200 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.42 E |
| SAMN07612656 | sex | female | R2 | 0.75 | external.gmrepo source | sex: Female |
| SAMN07612656 | subject_id | SAMN07612656 | R4 | 0.60 | design.one_sample_per_subject:description | the gut microbiota from 75 patients with GDM and 70 healthy pregnant women |
Sequencing
145 runs over 145 samples · mean 7.15 Gbp per run (median 6.90 Gbp, total 1,036.16 Gbp; 145 runs with a base count) · layout PAIRED 145 · platform ILLUMINA 145 · models HiSeq X Ten (145) · 89% of runs with a Sandpiper profile · first public 2017-09-30
Authors (31)
Liang W first · Feng Y · Yang D · Qin J · Zhi X · Wu W · Jie Q last · Zhang K first · Hu M · Yang W · Hu Z · Rong Y · Luo B · Wang M · Cheng Y · Zhang R · Lv N · Zhou Q · Zhang X last · Du H first · Lin Q · He X · Yang B · Huang Y · Li Q · Wang Y · Wen R · Lin W · Li S · Zheng L · Ou Z last
Downloads
PRJNA401977.csv.gz (4.7 KB) · parquet (77.1 KB) — all 145 samples, every field with route and confidence · PRJNA401977_determinations.csv.gz (10.5 KB) — 1,305 evidence rows