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PRJNA417283 SRP133577

Infant Gut, Skin, and ICU Environment Microbiome Study

human metagenome Raw sequence reads

86 samples from an intensive care unit meta-analysis of infant gut, skin, and environmental microbiomes; country and age data are not reported. Design combines case-control and longitudinal cohort elements. machine-written summary

86 samples · 86 runs · Infant / toddler · 2018 · 4.65 Gbp / sample

Sources
○Sequence archive○Abstract / description✓Full text 258–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
○ Sequence archiverecords read; no usable sample values
○ Abstract / descriptionread; no usable statement
✓ Full text258 sample values (location locality, location region, location site) · PMC6026636
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet · share metadata
– Human verifiednot yet checked by a person · I checked this project — verify it
Interventions

intervention — arms not resolved

Other administered intervention (see intervention_detail) design observational_with_procedure · population preterm_nicu · NICU environment comparison (shared-space vs single-family room); antibiotics observed, not assigned

“infants in a shared-space NICU (old NICU) and a single-family room NICU” — abstract:29988506 (study level; per-sample arms are in the intervention column below)

Samples at a glance
Age
unknown86
Body site
unknown86
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 10 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 72 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 4 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 4.65 Gbp per sample0130Gbp
Community composition
Klebsiella 16.1%Staphylococcus 13.8%Cutibacterium 10.0%Escherichia 5.6%Veillonella 4.7%Enterococcus 3.1%Haemophilus_D 2.4%Bifidobacterium 2.0%Corynebacterium 1.7%Varibaculum 1.7%Streptococcus 1.6%Phocaeicola 1.2%not assigned to a genus 20.6%other genera 15.5%

Genera, mean relative abundance over 80 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country0 0%
health_condition0 0%
subject_id0 0%
detailed_location86 100%
location_locality86 100%86
location_region86 100%86
location_site86 100%86
Papers (3)
  • Comparison of Infant Gut and Skin Microbiota, Resistome and Virulome Between Neonatal Intensive Care Unit (NICU) Environments. PMID 29988506 PMC6026636 curated
  • (no title) curated
  • Colibactin genes are highly prevalent in the developing infant gut microbiome. PMID 41405404 PMC12716031 curated
Details
Archive description

Meta-analysis of Infant Gut, Skin, and Environmental Microbiome from an Intensive Care Unit

How this project entered the registry

Classified as human gut / stool / skin / other human site shotgun DNA metagenome of infant / toddler by sonnet_x2 with confidence 0.60. Assay shotgun_dna.

  • host run.host_tax_id · “9606”
  • host run.scientific_name · “human metagenome”
  • body site study.description · “Infant Gut, Skin, and Environmental Microbiome”
  • life stage study.description · “Infant Gut, Skin, and Environmental Microbiome”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN08616968location_localityFalls ChurchR30.70paper.fulltext.methodsInova Fairfax Hospital, Falls Church, Virginia
SAMN08616968location_regionVirginiaR30.70paper.fulltext.methodsInova Fairfax Hospital, Falls Church, Virginia
SAMN08616968location_siteInova Fairfax Hospital NICUR30.70paper.fulltext.methodsInova Fairfax Hospital, Falls Church, Virginia
Sequencing

86 runs over 86 samples · mean 4.96 Gbp per run (median 4.65 Gbp, total 426.79 Gbp; 86 runs with a base count) · layout SINGLE 86 · platform ILLUMINA 86 · models Illumina HiSeq 2500 (86) · 93% of runs with a Sandpiper profile · first public 2018-03-03

Authors (25)

Hourigan SK first · Subramanian P · Hasan NA · Ta A · Klein E · Chettout N · Huddleston K · Deopujari V · Levy S · Baveja R · Clemency NC · Baker RL · Niederhuber JE · Colwell RR last · Chaudhary PP first · O'Laughlin B · Kumar PS · Dabdoub SM · Myles IA · McCauley KE · Strength R · Robbins ES · Chen Q · Namasivyam S · Maxwell G

Help complete this project

4 of the 4 core fields are below 50% coverage: age_category, country, health_condition, subject_id. Share metadata

Downloads

PRJNA417283.csv.gz (2.8 KB) · parquet (73.0 KB) — all 86 samples, every field with route and confidence · PRJNA417283_determinations.csv.gz (1.4 KB) — 258 evidence rows

Samples (86 · every field this project has values for · hover a cell for its source)
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