Gut microbiome in fibromyalgia vs healthy controls
A case-control study comparing the gut microbiome of fibromyalgia patients and healthy controls using 16S rRNA and metagenomic sequencing, based on 156 samples (mostly adults); country not reported. machine-written summary
156 samples · 156 runs · CA · Adult · 2019 · 2.43 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 810 sample values (age, family role, health condition, health condition detail, sex, shared setting type, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| ✓ External resources | 156 sample values (country) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
families — not resolvedhouseholds — not resolved
Fibromyalgia study: 11 first-degree relatives and 20 same-household controls of patients; index patient not identified per control.
Genera, mean relative abundance over 145 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 156 | 100% | ||||
| country | 156 | 100% | 156 | |||
| health_condition | 156 | 100% | 156 | |||
| subject_id | 156 | 100% | 156 | |||
| health_condition_detail | 156 | 100% | 156 | |||
| sex | 156 | 100% | 156 | |||
| age_at_collection_days | 155 | 99% | 155 | |||
| shared_setting_type | 20 | 13% | 20 | |||
| family_role | 11 | 7% | 11 |
Archive description
A cross-sectional comparative study aiming to characterise the gut microbiome of fibromyalgia (FM) patients as compared to healthy controls. Fecal samples were analysed using 16S rRNA and metagenomic sequencing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Gut microbiome in individuals”
- body site study.description · “to characterise the gut microbiome of fibromyalgia”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN10886000 | age_at_collection_days | 18993.0 | R1 | 0.70 | sample.attr.age | 52 |
| SAMN10886036 | age_at_collection_days | 43464.8 | R1 | 0.85 | biosample.attribute:age | 119 |
| SAMN10886000 | country | CA | R2 | 0.75 | external.gmrepo source | country: Canada |
| SAMN10886027 | family_role | other_relative | R1 | 0.85 | biosample.attribute:disease | First-degree relation with a patient (Control Group) |
| SAMN10886000 | health_condition | other_disease | R1 | 0.70 | biosample_attr | Patient with Fibromylagia (FM Group) |
| SAMN10886000 | health_condition_detail | Patient with Fibromylagia (FM Group) | R1 | 0.90 | sample.attr.disease | Patient with Fibromylagia (FM Group) |
| SAMN10886000 | sex | female | R1 | 0.90 | sample.attr.sex | female |
| SAMN10886006 | shared_setting_type | household | R1 | 0.85 | biosample.attribute:disease | Same Household adress as Patient (Control Group) |
| SAMN10886000 | subject_id | Pt_Fibro_122 | R1 | 0.85 | biosample.attribute:isolate | Pt_Fibro_122 |
Sequencing
156 runs over 156 samples · mean 2.48 Gbp per run (median 2.43 Gbp, total 386.96 Gbp; 156 runs with a base count) · layout PAIRED 156 · platform ILLUMINA 156 · models Illumina HiSeq 4000 (156) · 93% of runs with a Sandpiper profile · first public 2019-11-28
Authors (24)
Argentini C first · Lugli GA · Tarracchini C · Fontana F · Mancabelli L · Viappiani A · Anzalone R · Angelini L · Alessandri G · Longhi G · Bianchi MG · Taurino G · Bussolati O · Milani C · van Sinderen D · Turroni F · Ventura M last · De Biase R · Bocchio F · De Conto F · Nouvenne A · Ticinesi A · Meschi T · Cecchi R
Downloads
PRJNA521587.csv.gz (5.4 KB) · parquet (77.7 KB) — all 156 samples, every field with route and confidence · PRJNA521587_determinations.csv.gz (8.6 KB) — 966 evidence rows