Gut virome in PCOS vs healthy women, China (case-control)
93 fecal metagenome samples from women in China (50 with PCOS, 43 healthy controls), compared in a case-control design to characterize gut viral diversity and composition linked to PCOS. machine-written summary
93 samples · 93 runs · CN · Age unknown · 2019 · 9.34 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 450 sample values (collection date, country, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 279 sample values (location locality, location site, subject id) · PMC10734426, PMC11438002, PMC12527991, PMC7376369, PMC9424824 |
| ✓ Supplementary tables | 135 sample values (health condition, health condition detail) |
| ✓ External resources | 237 sample values (antibiotic exposure, health condition, health condition detail, sex) · from GMrepo v3, Meta2DB (LLNL) |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 80 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 93 | 100% | ||||
| country | 93 | 100% | 93 | |||
| health_condition | 93 | 100% | 93 | |||
| subject_id | 93 | 100% | 93 | |||
| antibiotic_exposure | 93 | 100% | 93 | |||
| collection_date | 93 | 100% | 93 | |||
| detailed_location | 93 | 100% | ||||
| health_condition_detail | 93 | 100% | 93 | |||
| latitude | 93 | 100% | 93 | |||
| location_locality | 93 | 100% | 93 | |||
| location_site | 93 | 100% | 93 | |||
| longitude | 93 | 100% | 93 | |||
| sex | 93 | 100% | 93 | |||
| location_region | 78 | 84% | 78 |
- Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome. 2019 PMID 31332392 PMC7376369 own_data
- Metagenomic-based characterization of the gut virome in patients with polycystic ovary syndrome. 2022 PMID 36051758 PMC9424824 own_data
- Gut microbial-derived 3,4-dihydroxyphenylacetic acid ameliorates reproductive phenotype of polycystic ovary syndrome. 2025 PMID 41112053 PMC12527991 own_data
- Cross-cohort single-nucleotide-variant profiling of gut microbiota suggests a novel gut-health assessment approach. 2023 PMID 37905808 PMC10734426 unsure
- Clinical significance of the genetically variable landscape of the gut microbiome in patients with gestational diabetes mellitus patients. 2024 PMID 39347390 PMC11438002 unsure
Archive description
gut microbiota of PCOS patients and healthy individuals
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.72. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN11342808 | antibiotic_exposure | no | R2 | 0.70 | external.meta2db source | antibiotics: FALSE |
| SAMN11342808 | collection_date | 2018-07-22 | R1 | 0.90 | biosample.attribute:collection_date | 2018-07-22 |
| SAMN11342808 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN11342808 | health_condition | healthy_control | R2 | 0.80 | paper.supp.Table_1.XLSX[Table S1!Group] | healthy control |
| SAMN11342851 | health_condition | other_disease | R2 | 0.75 | external.gmrepo source | phenotype: Polycystic Ovary Syndrome |
| SAMN11342808 | health_condition_detail | healthy control | R2 | 0.85 | paper.supp.Table_1.XLSX[Table S1!Group] | healthy control |
| SAMN11342893 | health_condition_detail | Polycystic Ovary Syndrome | R2 | 0.75 | external.gmrepo source | phenotype: Polycystic Ovary Syndrome |
| SAMN11342808 | latitude | 39.9200 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN11342808 | location_locality | Foshan | R3 | 0.70 | paper.fulltext.methods | First People's Hospital of Foshan |
| SAMN11342808 | location_region | Beijing | R1 | 0.60 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN11342808 | location_site | First People's Hospital of Foshan | R3 | 0.70 | paper.fulltext.methods | First People's Hospital of Foshan in 2022 |
| SAMN11342808 | longitude | 116.4600 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN11342808 | sex | female | R2 | 0.70 | external.meta2db source | host_sex: female |
| SAMN11342808 | subject_id | SAMN11342808 | R3 | 0.70 | design.one_sample_per_subject:fulltext | we analyzed the metagenomic sequencing dataset from fecal samples of 50 patients and 43 healthy individuals |
Sequencing
93 runs over 93 samples · mean 8.81 Gbp per run (median 9.34 Gbp, total 819.14 Gbp; 93 runs with a base count) · layout PAIRED 93 · platform ILLUMINA 93 · models Illumina HiSeq 2500 (93) · 86% of runs with a Sandpiper profile · first public 2019-07-06
Authors (69)
Qi X first · Yun C · Sun L · Xia J · Wu Q · Wang Y · Wang L · Zhang Y · Liang X · Gonzalez FJ · Patterson AD · Liu H · Mu L · Zhou Z · Zhao Y · Li R · Liu P · Zhong C · Pang Y · Jiang C · Qiao J last · Huang L first · Wu X · Guo S · Lv Y · Zhou P · Huang G · Duan Z · Sun W last · Ma C first · Jiang S · Teng F · Huang S · Zhang J last · Zhang K first · Hu M · Yang W · Hu Z · Rong Y · Luo B · Wang M · Cheng Y · Zhang R · Lv N · Zhou Q · Zhang X last · Li P first · Xie L · Zheng H · Feng Y · Mai F · Tang W · Wang J · Lan Z · Lv S · Jayawardana T · Koentgen S · Xu S · Wan Z · Chen Y · Xu H · Shen S · Zhang F · Yang Y · Hold G · He F · El-Omar EM · Yu G · Chen X last
Downloads
PRJNA530971.csv.gz (3.6 KB) · parquet (76.0 KB) — all 93 samples, every field with route and confidence · PRJNA530971_determinations.csv.gz (9.5 KB) — 1,101 evidence rows