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PRJNA579180 SRP226762

Gut microbiome in IBS vs healthy Mexican adults

Microbiome Profile in Irritable Bowel Syndrome and Healthy Controls from Mexican individuals

9 samples from adult Mestizo subjects in Mexico, comparing intestinal microbiota taxonomic composition between IBS patients and healthy controls in a case-control design. machine-written summary

9 samples · 9 runs · MX · Adult · 2020 · 19.20 Gbp / sample

Sources
✓Sequence archive 45○Abstract / description✓Full text 27○Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive45 sample values (age, collection date, health condition, health condition detail, sex)
○ Abstract / descriptionread; no usable statement
✓ Full text27 sample values (antibiotic exposure, country, location site) · PMC7098960
○ Supplementary tablesfiles read; no table could be matched to the samples
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
adult9
Condition
healthy_control5
ibs4
Sex
female6
male3
Country
MX9
Body site
primary9
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)all projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 9 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 19.20 Gbp per sample0130Gbp
Community composition
Phocaeicola 21.9%Escherichia 15.3%Faecalibacterium 5.0%Bacteroides 5.0%Mediterraneibacter 3.7%Allocoprococcus 0.8%Fusicatenibacter_A 0.7%Parabacteroides 0.7%Gallintestinimicrobium 0.7%Roseburia 0.6%Hominiventricola 0.5%not assigned to a genus 44.9%

Genera, mean relative abundance over 2 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category9 100%
country9 100%9
health_condition9 100%9
subject_id0 0%
age_at_collection_days9 100%9
antibiotic_exposure9 100%9
collection_date9 100%9
detailed_location9 100%
health_condition_detail9 100%9
location_site9 100%9
sex9 100%9
Papers (1)
  • Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals. 2020 PMID 32266159 PMC7098960 own_data
Details
Archive description

Data of taxonomic composition of the intestinal microbiota in IBS patients and healthy subjects from Mexico.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.description · “composition of the intestinal microbiota in IBS”
  • body site external_curation.infant_catalog · “body_site_call gut”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN13087259age_at_collection_days21915.0R10.70sample.attr.host_age60
SAMN13087259antibiotic_exposurenoR30.70paper.fulltext.methodsexcluded if they received antibiotics
SAMN13087259collection_date2015R10.90biosample.attribute:collection_date2015
SAMN13087259countryMXR30.70paper.fulltext.methodsrecruited at the Hospital General de México
SAMN13087259health_conditionibsR10.85biosample.attribute:gastrointest_disordIrritable Bowel Syndrome
SAMN13087259health_condition_detailbiopsiesR10.90sample.attr.liver_disordbiopsies
SAMN13087259location_siteHospital General de México Dr. Eduardo LiceagaR30.70paper.fulltext.methodsrecruited at the Hospital General de México Dr. Eduardo Liceaga
SAMN13087259sexfemaleR10.90sample.attr.host_sexfemale
Sequencing

9 runs over 9 samples · mean 20.34 Gbp per run (median 19.20 Gbp, total 183.07 Gbp; 9 runs with a base count) · layout PAIRED 9 · platform ILLUMINA 9 · models Illumina HiSeq 4000 (9) · 78% of runs with a Sandpiper profile · first public 2020-10-01

Authors (13)

Arredondo-Hernández R first · Schmulson M · Orduña P · López-Leal G · Zarate AM · Alanis-Funes G · Alcaraz LD · Santiago-Cruz R · Cevallos MA · Villa AR · Ponce-de-León Rosales S · López-Vidal Y · Consorcio Mexicano para el Estudio del Microbioma Humano last

Downloads

PRJNA579180.csv.gz (1.2 KB) · parquet (70.4 KB) — all 9 samples, every field with route and confidence · PRJNA579180_determinations.csv.gz (1.2 KB) — 72 evidence rows

Samples (9 · every field this project has values for · hover a cell for its source)
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