Gut microbiome response to polydextrose in healthy US adults
972 stool samples from healthy adult volunteers in California, USA, in a randomized, open-label intervention study evaluating gut microbiota structure and function responses to increasing polydextrose feeding amounts. machine-written summary
972 samples · 972 runs · US · Adult · 2020 · 0.15 Gbp / sample · cohort High-resolution temporal profiling of the human gu
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 8,748 sample values (collection date, country, intervention, intervention detail, latitude, location region, longitude, subject id) |
| ✓ Abstract / description | 972 sample values (health condition) |
| ○ Full text | read; no usable statement or table · PMC7386241 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention · arms resolved
32 people have samples in more than one arm.
Prebiotic / dietary fibre supplement design randomized_controlled_trial · population healthy_control · Polydextrose dietary glycan feeding, increasing doses, healthy subjects
“Increasing Feeding Amounts of Polydextrose (PDX)” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal
32 of 32 people sampled more than once (972 samples; median 32, up to 46 per person) · follow-up median 1 d (max 1 d) · median interval between samples 1 d (time from collection dates).
Each row is one person (2 shown of 32); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 701 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 972 | 100% | ||||
| country | 972 | 100% | 972 | |||
| health_condition | 972 | 100% | 972 | |||
| subject_id | 972 | 100% | 972 | |||
| collection_date | 972 | 100% | 972 | |||
| detailed_location | 972 | 100% | ||||
| intervention | 972 | 100% | 972 | |||
| intervention_detail | 972 | 100% | 972 | |||
| latitude | 972 | 100% | 972 | |||
| location_region | 972 | 100% | 972 | |||
| longitude | 972 | 100% | 972 | |||
| timepoint_label | 972 | 100% | 972 |
- High-resolution temporal profiling of the human gut microbiome reveals consistent and cascading alterations in response to dietary glycans. 2020 PMID 32620143 PMC7386241 unsure
Archive description
A Randomized, Open-Label Study to Evaluate the Effect of Increasing Feeding Amounts of Polydextrose (PDX) on Gut Microbiota Structure and Function Shifts in Healthy Subjects
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Human gut microbiome response to”
- body site study.description · “Polydextrose (PDX) on Gut Microbiota Structure and”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN13521429 | collection_date | 2017-07-19 | R1 | 0.90 | biosample.attribute:collection_date | 2017-07-19 |
| SAMN13521429 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: California |
| SAMN13521429 | health_condition | healthy_control | R4 | 0.50 | study.description | Healthy Subjects |
| SAMN13521429 | intervention | prebiotic_or_fibre | R1 | 0.90 | biosample.attribute:period | period: Feeding2 |
| SAMN13521429 | intervention_detail | PDX feeding period 2 (higher dose) | R1 | 0.90 | biosample.attribute:period | period: Feeding2 |
| SAMN13521429 | latitude | 33.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 33 N 117 W |
| SAMN13521429 | location_region | California | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: California |
| SAMN13521429 | longitude | -117.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 33 N 117 W |
| SAMN13521429 | subject_id | 201-024 | R1 | 0.85 | sample.attr.subject | 201-024 |
| SAMN13521429 | timepoint_label | Feeding2 | R1 | 0.85 | sample.attr.period | Feeding2 |
Sequencing
972 runs over 972 samples · mean 0.15 Gbp per run (median 0.15 Gbp, total 142.36 Gbp; 972 runs with a base count) · layout SINGLE 972 · platform ILLUMINA 972 · models HiSeq X Ten (972) · 72% of runs with a Sandpiper profile · first public 2020-06-16
Authors (14)
Creswell R first · Tan J · Leff JW · Brooks B · Mahowald MA · Thieroff-Ekerdt R · Gerber GK last · Tarracchini C first · Lugli GA · Mancabelli L · van Sinderen D · Turroni F · Ventura M · Milani C last
Downloads
PRJNA594610.csv.gz (20.9 KB) · parquet (100.2 KB) — all 972 samples, every field with route and confidence · PRJNA594610_determinations.csv.gz (52.3 KB) — 9,720 evidence rows