Gut phages & bacteria in stunted Bangladeshi children
1 sample from a study of gut bacterial and bacteriophage communities in Bangladeshi children under 38 months, comparing stunted and non-stunted children. machine-written summary
40 samples · 40 runs · BD · Child · 2020 · 0.31 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 32 sample values (health condition, health condition detail) |
| ✓ Abstract / description | 80 sample values (country, location region) |
| ○ Full text | read; no usable statement or table · PMC7013830 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 40 | 100% | ||||
| country | 40 | 100% | 40 | |||
| health_condition | 16 | 40% | 16 | |||
| subject_id | 0 | 0% | ||||
| detailed_location | 40 | 100% | ||||
| location_region | 40 | 100% | 40 | |||
| health_condition_detail | 16 | 40% | 16 |
- Bacteriophages Isolated from Stunted Children Can Regulate Gut Bacterial Communities in an Age-Specific Manner. 2020 PMID 32053789 PMC7013830 cites_accession
Archive description
Child stunting is a significant health concern in low and middle-income countries. Delayed and reduced growth or stunting results from nutrition deficiencies, genetics, and altered gut microbiota. Recent studies have shown that gut bacteria of stunted children are different from their normal counterparts, generally with lower Firmicutes/Proteobacteria ratio. While the role of bacteriophages (phages for short) in regulating bacterial populations in the environment is well studied, their role in gut dysbiosis is unknown. In collaboration with the International Centre for Diarrhoeal Disease Research, Bangladesh, we have studied the role of phages in healthy and stunted children from Bangladesh. We show that these children harbor distinct gut bacteriophages relative to their non-stunted counterparts. Furthermore, the gut bacteriophages isolated from this children are infectious and can regulate bacterial abundance and composition in an age-specific manner, highlighting their possible role in the pathophysiology of child stunting.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of child by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “gut bacterial communities isolated from stunted children”
- life stage study.title · “stunted children in an age specific manner”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SRR10662781 | country | BD | R4 | 0.50 | paper.abstract | Bangladeshi stunted children younger than 38 months |
| SRR10662781 | health_condition | malnutrition | R1 | 0.70 | sample.name_rule:library_names | Db-G3-S1 |
| SRR10662781 | health_condition_detail | stunted | R1 | 0.70 | sample.name_rule:library_names | Db-G3-S1 |
| SRR10662781 | location_region | Bangladesh | R4 | 0.45 | ena.study_description | International Centre for Diarrhoeal Disease Research, Bangladesh |
Sequencing
40 runs over 40 samples · mean 0.35 Gbp per run (median 0.31 Gbp, total 14.05 Gbp; 40 runs with a base count) · layout PAIRED 40 · platform ILLUMINA 40 · models Illumina MiSeq (40) · 0% of runs with a Sandpiper profile · first public 2020-02-18
Authors (0)
No author record.
Downloads
PRJNA594824.csv.gz (1.6 KB) · parquet (69.9 KB) — all 40 samples, every field with route and confidence · PRJNA594824_determinations.csv.gz (1.5 KB) — 112 evidence rows