FMT for TKI-induced diarrhoea in renal cell carcinoma, Rome
45 gut metagenome samples from adult metastatic renal cell carcinoma patients in Rome, Italy, in a randomised trial comparing faecal microbiota transplantation versus placebo for tyrosine-kinase-inhibitor-induced diarrhoea. machine-written summary
45 samples · 45 runs · IT · Adult · 2020 · 2.89 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 281 sample values (collection date, country, health condition, intervention, location locality, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 45 sample values (antibiotic exposure) · PMC12180181, PMC7455693 |
| ✓ Supplementary tables | 64 sample values (health condition, health condition detail) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design randomized_controlled_trial · population other_cancer · FMT vs placebo FMT for TKI-induced diarrhoea in RCC patients
“randomised to receive FMT from healthy donors or placebo FMT” — abstract:32859933 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
10 of 23 people sampled more than once (32 samples; median 3, up to 4 per person). Schedule stated by the source: “Donor-FMT patients sampled at t0, t7, t15, t30 days post-treatment; placebo patients sampled once (single timepoint, no suffix).” (time origin: intervention start (FMT/placebo treatment)); stated follow-up 56 d.
Genera, mean relative abundance over 44 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 45 | 100% | ||||
| country | 45 | 100% | 45 | |||
| health_condition | 45 | 100% | 26 | 19 | ||
| subject_id | 45 | 100% | 45 | |||
| antibiotic_exposure | 45 | 100% | 45 | |||
| collection_date | 45 | 100% | 45 | |||
| detailed_location | 45 | 100% | ||||
| health_condition_detail | 45 | 100% | 45 | |||
| location_locality | 45 | 100% | 45 | |||
| timepoint_label | 43 | 96% | 43 | |||
| intervention | 32 | 71% | 32 |
- Faecal microbiota transplantation for the treatment of diarrhoea induced by tyrosine-kinase inhibitors in patients with metastatic renal cell carcinoma. 2020 PMID 32859933 PMC7455693 own_data
- Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantation. 2025 PMID 40542451 PMC12180181 unsure
Archive description
Metagenomes from patients participating in a randomised clinical trial receiving either FMT from donors or a placebo control.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN15428652 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | recent (<6 weeks) therapy with drugs that could possibly alter gut microbiota |
| SAMN15428652 | collection_date | 2019-04-05 | R1 | 0.90 | biosample.attribute:collection_date | 2019-04-05 |
| SAMN15428652 | country | IT | R1 | 0.90 | sample.attr.geo_loc_name | Italy: Rome |
| SAMN15428658 | health_condition | other_cancer | R1 | 0.50 | biosample_attr | DMT_Patient02_Week4 |
| SAMN15428652 | health_condition | other_disease | R2 | 0.85 | paper.supp.40168_2025_2046_MOESM8_ESM.xlsx[S2!Condition] | TKI_related_diarrhea |
| SAMN15428652 | health_condition_detail | TKI_related_diarrhea | R2 | 0.85 | paper.supp.40168_2025_2046_MOESM8_ESM.xlsx[S2!Condition] | TKI_related_diarrhea |
| SAMN15428652 | intervention | fmt | R1 | 0.70 | sample.name_rule:title | DFMT_01_t0 |
| SAMN15428652 | location_locality | Rome | R1 | 0.85 | biosample.attribute:geo_loc_name | Italy: Rome |
| SAMN15428652 | subject_id | 01 | R1 | 0.85 | biosample.attribute:group | group: DMT_Patient01_Week0 |
| SAMN15428659 | subject_id | 03 | R1 | 0.70 | sample.name_rule:title | DFMT_03_t0 |
| SAMN15428652 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:title | DFMT_01_t0 |
| SAMN15428684 | timepoint_label | week 0 | R1 | 0.85 | biosample.attribute:group | group: PMT_Patient01_Week0 |
Sequencing
45 runs over 45 samples · mean 8.22 Gbp per run (median 2.89 Gbp, total 369.91 Gbp; 45 runs with a base count) · layout PAIRED 45 · platform ILLUMINA 45 · models Illumina NovaSeq 6000 (45) · 98% of runs with a Sandpiper profile · first public 2020-07-03 – 2020-07-11
Authors (25)
Ianiro G first · Rossi E · Thomas AM · Schinzari G · Masucci L · Quaranta G · Settanni CR · Lopetuso LR · Armanini F · Blanco-Miguez A · Asnicar F · Consolandi C · Iacovelli R · Sanguinetti M · Tortora G · Gasbarrini A · Segata N · Cammarota G last · Ji S first · Ahmad F · Peng B · Yang Y · Su M · Zhao X · Vatanen T last
Downloads
PRJNA643802.csv.gz (2.1 KB) · parquet (71.5 KB) — all 45 samples, every field with route and confidence · PRJNA643802_determinations.csv.gz (4.4 KB) — 390 evidence rows