Gut-brain axis in elderly at AD risk, Norwich, longitudinal
81 gut metagenome samples from elderly adults in Norwich, UK, at differential genetic risk for Alzheimer's disease, collected longitudinally at baseline, 6 months, and 12 months. machine-written summary
81 samples · 81 runs · GB · Elderly · 2022 · 7.82 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 567 sample values (collection date, country, latitude, location locality, location region, longitude, subject id) |
| – Abstract / description | no abstract or project description |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “stool at baseline, 6 months, and 12 months” (time origin: enrolment); stated follow-up 12 mo.
Genera, mean relative abundance over 70 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 81 | 100% | ||||
| country | 81 | 100% | 81 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 81 | 100% | 81 | |||
| collection_date | 81 | 100% | 81 | |||
| detailed_location | 81 | 100% | ||||
| latitude | 81 | 100% | 81 | |||
| location_locality | 81 | 100% | 81 | |||
| location_region | 81 | 100% | 81 | |||
| longitude | 81 | 100% | 81 |
Archive description
This study (a pilot to the MOTION Study) is a longitudinal observational multi-domain pilot study that investigates the Gut-Brain axis in healthy elderly at differential genetic risk for developing Alzheimer's disease (AD) and compares this to a small group of AD patients. The project explores how the gut microbiome changes with healthy ageing over time and investigates the role of potential risk factors for AD on cognition, brain health and microbiome profiles. The gut microbiota is assessed at three time points (baseline, 6 months, 12 months) over the period of 12 months using whole metagenomic shotgun sequencing.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of elderly by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.description · “The gut microbiota is assessed”
- life stage study.description · “healthy elderly at differential genetic risk”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN16247182 | collection_date | 2018-03-23 | R1 | 0.90 | biosample.attribute:collection_date | 2018-03-23 |
| SAMN16247182 | country | GB | R1 | 0.90 | sample.attr.geo_loc_name | United Kingdom: Norwich |
| SAMN16247182 | latitude | 52.6309 | R1 | 0.90 | biosample.attribute:lat_lon | 52.6309 N 1.2974 E |
| SAMN16247182 | location_locality | Norwich | R1 | 0.85 | biosample.attribute:geo_loc_name | United Kingdom: Norwich |
| SAMN16247182 | location_region | England | R1 | 0.60 | biosample.attribute:lat_lon | 52.6309 N 1.2974 E |
| SAMN16247182 | longitude | 1.2974 | R1 | 0.90 | biosample.attribute:lat_lon | 52.6309 N 1.2974 E |
| SAMN16247182 | subject_id | subject_1 | R1 | 0.70 | sample.name_rule:alias | subject_1 |
Sequencing
81 runs over 81 samples · mean 8.03 Gbp per run (median 7.82 Gbp, total 650.33 Gbp; 81 runs with a base count) · layout PAIRED 81 · platform ILLUMINA 81 · models Illumina HiSeq 3000 (81) · 86% of runs with a Sandpiper profile · first public 2022-10-04
Authors (0)
No author record.
Downloads
PRJNA665245.csv.gz (3.2 KB) · parquet (74.0 KB) — all 81 samples, every field with route and confidence · PRJNA665245_determinations.csv.gz (5.0 KB) — 567 evidence rows