Gut metagenome, hypertension patients, Beijing
40 samples from a case-control study in Beijing, China, comparing gut metagenomes of primary hypertension patients on antihypertensive medication with healthy adults. machine-written summary
40 samples · 60 runs · CN · Adult · 2023 · 12.21 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 320 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 80 sample values (antibiotic exposure, location site) · PMC8600050 |
| ✓ Supplementary tables | 83 sample values (age, bmi, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
design observational_with_procedure
longitudinal — not resolved
Schedule stated by the source: “Mouse subset sampled at two timepoints: after 5 days tamoxifen treatment (before minipump implantation) and on day 7 of AngII stimulation; human samples single timepoint.” (time origin: intervention_start); stated follow-up 7 d.
Genera, mean relative abundance over 56 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 40 | 100% | ||||
| country | 40 | 100% | 40 | |||
| health_condition | 40 | 100% | 40 | |||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 40 | 100% | 40 | |||
| collection_date | 40 | 100% | 40 | |||
| detailed_location | 40 | 100% | ||||
| health_condition_detail | 40 | 100% | 40 | |||
| latitude | 40 | 100% | 40 | |||
| location_locality | 40 | 100% | 40 | |||
| location_region | 40 | 100% | 40 | |||
| location_site | 40 | 100% | 40 | |||
| longitude | 40 | 100% | 40 | |||
| sex | 38 | 95% | 38 | |||
| age_at_collection_days | 37 | 92% | 37 | |||
| bmi | 8 | 20% | 8 |
- Glycan Biosynthesis Ability of Gut Microbiota Increased in Primary Hypertension Patients Taking Antihypertension Medications and Potentially Promoted by Macrophage-Adenosine Monophosphate-Activated Protein Kinase. 2021 PMID 34803940 PMC8600050 own_data
Archive description
gut metagenome in hyptertension patients and hyptertension mice Raw sequence reads
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “hyptertensive gut metagenome in patients”
- body site study.description · “gut metagenome in hyptertension”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN17132978 | age_at_collection_days | 13514.0 | R2 | 0.85 | paper.supp.Presentation_1.zip/Supplementary Table 1.xls[Supplementary Table 1!Age, year] | C21: 37 |
| SAMN17132978 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | excluded if they received antibiotics or probiotics within 4 weeks |
| SAMN17132978 | bmi | 25.90 | R2 | 0.85 | paper.supp.Presentation_1.zip/Supplementary Table 1.xls[Supplementary Table 1!BMI, kg/m2] | C21: 25.9 |
| SAMN17132978 | collection_date | 2019-11-03 | R1 | 0.90 | biosample.attribute:collection_date | 2019-11-03 |
| SAMN17132978 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Beijing |
| SAMN17132978 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:alias | C21 |
| SAMN17132978 | health_condition_detail | C | R1 | 0.70 | sample.name_rule:alias | C21 |
| SAMN17132978 | latitude | 39.9200 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN17132978 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Beijing |
| SAMN17132978 | location_region | Beijing | R1 | 0.60 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN17132978 | location_site | Anzhen Hospital | R3 | 0.70 | paper.fulltext.methods | inpatients of the Department of Hypertension |
| SAMN17132978 | longitude | 116.4600 | R1 | 0.90 | biosample.attribute:lat_lon | 39.92 N 116.46 E |
| SAMN17132978 | sex | male | R2 | 0.85 | paper.supp.Presentation_1.zip/Supplementary Table 1.xls[Supplementary Table 1!Gender] | C21: M |
Sequencing
60 runs over 40 samples · mean 12.40 Gbp per run (median 12.21 Gbp, total 744.11 Gbp; 60 runs with a base count) · layout PAIRED 60 · platform ILLUMINA 60 · models Illumina HiSeq 2500 (60) · 93% of runs with a Sandpiper profile · first public 2023-01-02
Downloads
PRJNA685581.csv.gz (2.2 KB) · parquet (72.7 KB) — all 40 samples, every field with route and confidence · PRJNA685581_determinations.csv.gz (4.6 KB) — 483 evidence rows