Gut microbiome in pediatric myasthenia gravis, China
123 fecal samples from children/adolescents in China, comparing pediatric ocular myasthenia gravis patients to age- and gender-matched healthy controls in a case-control design. machine-written summary
123 samples · 123 runs · CN · Child · 2021 · 11.18 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 713 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude) |
| ✓ Abstract / description | 3 sample values (health condition detail) |
| ○ Full text | read; no usable statement or table · PMC11622613 |
| ✓ Supplementary tables | 251 sample values (age, health condition detail, sex) |
| ✓ External resources | 70 sample values (health condition, health condition detail) · from GMrepo v3 |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 117 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 123 | 100% | ||||
| country | 123 | 100% | 123 | |||
| health_condition | 101 | 82% | 49 | 52 | ||
| subject_id | 0 | 0% | ||||
| collection_date | 123 | 100% | 123 | |||
| detailed_location | 123 | 100% | ||||
| health_condition_detail | 123 | 100% | 49 | 71 | 3 | |
| latitude | 123 | 100% | 123 | |||
| location_region | 123 | 100% | 123 | |||
| longitude | 123 | 100% | 123 | |||
| age_at_collection_days | 99 | 80% | 99 | |||
| sex | 99 | 80% | 99 |
- Metagenome-wide association study of gut microbiome revealed potential microbial marker set for diagnosis of pediatric myasthenia gravis. 2021 PMID 34233671 PMC8265136 own_data
- Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study. 2024 PMID 39632378 PMC11622613 own_data
Archive description
Metageomics sequencing data of Rheumatoid arthritis (RA) in Hebei, China
How this project entered the registry
Classified as human gut / stool / eye / ear shotgun DNA metagenome of child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- body site study.title · “association study of gut microbiome revealed potential”
- body site external_curation.infant_catalog · “body_site_call gut”
- body site study.title · “etiology of Pediatric Ocular Myasthenia Gravis”
- life stage external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- life stage study.title · “potential etiology of Pediatric Ocular Myasthenia Gravis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN17190386 | age_at_collection_days | 4383 | R2 | 0.85 | paper.supp.12916_2021_2034_MOESM4_ESM.xlsx[Table s-2!Age(year)] | 12 |
| SAMN17190386 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMN17190386 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China |
| SAMN17190441 | health_condition | healthy_control | R1 | 0.70 | sample.name_rule:sample_description | HC |
| SAMN17190387 | health_condition | autoimmune_inflammatory | R2 | 0.75 | external.gmrepo source | phenotype: Myasthenia Gravis |
| SAMN17190441 | health_condition_detail | HC | R1 | 0.70 | sample.name_rule:sample_description | HC |
| SAMN17190386 | health_condition_detail | MG | R2 | 0.85 | paper.supp.12916_2021_2034_MOESM4_ESM.xlsx[Table s-6!Disease state] | MG |
| SAMN17190424 | health_condition_detail | Myasthenia Gravis | R2 | 0.75 | external.gmrepo source | phenotype: Myasthenia Gravis |
| SAMN17190395 | health_condition_detail | mixed_case_control: 53 pediatric MG patients vs 46 healthy controls | R4 | 0.50 | paper.abstract | 53 pediatric MG patients and 46 age- and gender-matched healthy controls |
| SAMN17190386 | latitude | 38.0300 | R1 | 0.90 | biosample.attribute:lat_lon | 38.03 N 114.26 E |
| SAMN17190386 | location_region | Henan Sheng | R1 | 0.60 | biosample.attribute:lat_lon | 38.03 N 114.26 E |
| SAMN17190386 | longitude | 114.2600 | R1 | 0.90 | biosample.attribute:lat_lon | 38.03 N 114.26 E |
| SAMN17190386 | sex | male | R2 | 0.85 | paper.supp.12916_2021_2034_MOESM4_ESM.xlsx[Table s-2!Gender] | M |
Sequencing
123 runs over 123 samples · mean 11.40 Gbp per run (median 11.18 Gbp, total 1,402.31 Gbp; 123 runs with a base count) · layout PAIRED 123 · platform ILLUMINA 123 · models Illumina HiSeq 4000 (123) · 95% of runs with a Sandpiper profile · first public 2021-06-08
Authors (28)
Liu P first · Jiang Y · Gu S · Xue Y · Yang H · Li Y · Wang Y · Yan C · Jia P · Lin X · Qi G last · Tarracchini C first · Fontana F · Mancabelli L · Lugli GA · Alessandri G · Turroni F · Ventura M · Milani C last · Hu W · Lin B · Ma T · Zhang Z · Zhou R · Kwok LY · Sun Z · Zhu C · Zhang H last
Downloads
PRJNA688881.csv.gz (4.4 KB) · parquet (75.6 KB) — all 123 samples, every field with route and confidence · PRJNA688881_determinations.csv.gz (7.3 KB) — 1,037 evidence rows