Probio-M9 probiotic trial in stressed adults, Hohhot, China
24 gut microbiome samples from stressed adult postgraduate students in Hohhot, China, in a placebo-controlled intervention trial testing the probiotic Lactobacillus rhamnosus Probio-M9. machine-written summary
24 samples · 24 runs · CN · Adult · 2022 · 7.56 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 144 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 48 sample values (health condition, health condition detail) · PMC8535744 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population healthy_control · Lactobacillus rhamnosus Probio-M9 oral probiotic for 21 days vs placebo
“received oral Probio-M9 for 21 days” — abstract:34681433 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Baseline (0 d) before intervention, then follow-up at 7 d, 14 d, and 21 d during 21-day intervention; fecal samples collected before and after intervention.” (time origin: intervention_start); stated follow-up 21 d.
Genera, mean relative abundance over 21 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 24 | 100% | ||||
| country | 24 | 100% | 24 | |||
| health_condition | 24 | 100% | 24 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 24 | 100% | 24 | |||
| detailed_location | 24 | 100% | ||||
| health_condition_detail | 24 | 100% | 24 | |||
| latitude | 24 | 100% | 24 | |||
| location_locality | 24 | 100% | 24 | |||
| location_region | 24 | 100% | 24 | |||
| longitude | 24 | 100% | 24 |
- Lactobacillus rhamnosus Probio-M9 Improves the Quality of Life in Stressed Adults by Gut Microbiota. 2021 PMID 34681433 PMC8535744 own_data
Archive description
Adult gut microbiota
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “Adult gut microbiota”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “life in stressed adults”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN18273645 | collection_date | 2018-11 | R1 | 0.90 | biosample.attribute:collection_date | 2018-11 |
| SAMN18273645 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Hohhot |
| SAMN18273645 | health_condition | healthy_control | R3 | 0.70 | paper.fulltext.methods | recruited twelve healthy graduate students |
| SAMN18273645 | health_condition_detail | healthy graduate students, stressed adults | R3 | 0.70 | paper.fulltext.methods | recruited twelve healthy graduate students |
| SAMN18273645 | latitude | 40.8200 | R1 | 0.90 | biosample.attribute:lat_lon | 40.82 N 111.65 E |
| SAMN18273645 | location_locality | Hohhot | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Hohhot |
| SAMN18273645 | location_region | Inner Mongolia | R1 | 0.60 | biosample.attribute:lat_lon | 40.82 N 111.65 E |
| SAMN18273645 | longitude | 111.6500 | R1 | 0.90 | biosample.attribute:lat_lon | 40.82 N 111.65 E |
Sequencing
24 runs over 24 samples · mean 7.73 Gbp per run (median 7.56 Gbp, total 185.62 Gbp; 24 runs with a base count) · layout PAIRED 24 · platform ILLUMINA 24 · models HiSeq X Ten (24) · 88% of runs with a Sandpiper profile · first public 2022-01-01
Downloads
PRJNA713865.csv.gz (1.5 KB) · parquet (70.8 KB) — all 24 samples, every field with route and confidence · PRJNA713865_determinations.csv.gz (1.8 KB) — 192 evidence rows