Gut bacterial, fungal microbiota in tuberculosis treatment
99 fecal samples from naive TB patients undergoing first-line anti-TB drug treatment and healthy subjects, analyzed by 16S rRNA and ITS2 amplicon sequencing in a follow-up study. machine-written summary
99 samples · 198 runs · CN · Age unknown · 2021 · 0.21 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 396 sample values (collection date, country, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10557844, PMC8672887 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design single_arm_before_after · population other_infection · First-line anti-tuberculosis drug treatment, fecal sampling at multiple time points (0, 2, 6 months)
“naive TB patients who received first-line anti-TB drug treatment” — abstract:34908436 (study level; per-sample arms are in the intervention column below)
longitudinal
29 of 51 people sampled more than once (77 samples; median 3, up to 3 per person) · follow-up median 6 mo (max 15 mo) · median interval between samples 2 mo (time from collection dates). Schedule stated by the source: “Fecal samples collected at multiple visits (sample names indicate timepoints 0-3, e.g., S48_0, S48_1, _2, _3) during anti-TB drug treatment follow-up” (time origin: intervention/treatment start).
Each row is one person (29 shown); dots are samples at days since that person's first sample.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 99 | 100% | 99 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 99 | 100% | 99 | |||
| collection_date | 99 | 100% | 99 | |||
| timepoint_label | 99 | 100% | 99 |
- Gut Mycobiota Dysbiosis in Pulmonary Tuberculosis Patients Undergoing Anti-Tuberculosis Treatment. 2021 PMID 34908436 PMC8672887 cites_accession
- Identification of microbial markers associated with lung cancer based on multi-cohort 16 s rRNA analyses: A systematic review and meta-analysis. 2023 PMID 37676050 PMC10557844 cites_accession
Archive description
Investigate the role of the gut microbiota in TB patients.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.70. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.description · “TB patients”
- body site study.title · “Gut microbiota and tuberculosis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN18388704 | collection_date | 2019-04-03 | R1 | 0.85 | biosample.attribute:collection_date | 2019-04-03 |
| SAMN18388704 | country | CN | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Beijing |
| SAMN18388704 | subject_id | 5 | R1 | 0.70 | sample.name_rule:alias | 5_1 |
| SAMN18388704 | timepoint_label | 1 | R1 | 0.70 | sample.name_rule:alias | 5_1 |
Sequencing
198 runs over 99 samples · mean 0.10 Gbp per run (median 0.10 Gbp, total 20.71 Gbp; 198 runs with a base count) · layout PAIRED 198 · platform ILLUMINA 198 · models Illumina HiSeq 2500 (198) · 0% of runs with a Sandpiper profile · first public 2021-03-23
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA715947.csv.gz (3.5 KB) · parquet (73.7 KB) — all 99 samples, every field with route and confidence · PRJNA715947_determinations.csv.gz (4.5 KB) — 396 evidence rows