Maternal probiotic exposure, perinatal microbiome, Sweden
355 samples from a feasibility study in Göteborg, Sweden, examining maternal probiotic intervention and perinatal seeding of commensal microbes during pregnancy. Design and participant details are not specified. machine-written summary
355 samples · 355 runs · SE · Infant / toddler · 2021 · 0.11 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,873 sample values (collection date, country, health condition, health condition detail, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Probiotic (live microorganisms; single strain or mixture) design single_arm_before_after · population pregnancy_postpartum · Probiotic supplementation during pregnancy for perinatal microbiome seeding
“Feasibility Study on probiotic delivery and perinatal microbiome seeding” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolvedmother–infant — not resolved
25 of 25 people sampled more than once (111 samples; median 5, up to 5 per person). Schedule stated by the source: “Visits V1, V2, V3 and Delivery timepoints per subject_id”.
36 subjects (mothers+infants) linked via generation attribute; maternal probiotic/perinatal seeding study implies mother-infant pairs..
Genera, mean relative abundance over 75 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 355 | 100% | 355 | |||
| health_condition | 232 | 65% | 232 | |||
| subject_id | 355 | 100% | 355 | |||
| collection_date | 355 | 100% | 355 | |||
| timepoint_label | 344 | 97% | 344 | |||
| health_condition_detail | 232 | 65% | 232 |
- De novo identification of microbial contaminants in low microbial biomass microbiomes with Squeegee. 2022 PMID 36357382 PMC9649624 cites_accession
Archive description
Feasibility Study on probiotic delivery and perinatal microbiome seeding during Pregnancy
How this project entered the registry
Classified as human gut / stool / oral cavity / vaginal / urogenital shotgun DNA metagenome of infant / toddler and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- body site run.scientific_name · “human oral metagenome”
- body site run.scientific_name · “human vaginal metagenome”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “The role of maternal exposures on commensal”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN18880492 | collection_date | 2018-01 | R1 | 0.85 | biosample.attribute:collection_date | 2018-01 |
| SAMN18880492 | country | SE | R1 | 0.90 | biosample_attr | Sweden: Goteborg |
| SAMN18880503 | health_condition | pregnancy_postpartum | R1 | 0.85 | biosample.attribute:generation | generation: Maternal |
| SAMN18880503 | health_condition_detail | Maternal | R1 | 0.85 | biosample.attribute:generation | generation: Maternal |
| SAMN18880492 | subject_id | ['blk_160014532_2', 'KitNeg'] | R1 | 0.85 | biosample_attr | ['blk_160014532_2', 'KitNeg'] |
| SAMN18880503 | timepoint_label | Delivery | R1 | 0.80 | biosample_attr | Delivery |
Sequencing
355 runs over 355 samples · mean 1.45 Gbp per run (median 0.11 Gbp, total 514.79 Gbp; 355 runs with a base count) · layout PAIRED 355 · platform ILLUMINA 355 · models HiSeq X Ten (355) · 45% of runs with a Sandpiper profile · first public 2021-05-07
Authors (0)
No author record.
Downloads
PRJNA725597.csv.gz (10.6 KB) · parquet (83.7 KB) — all 355 samples, every field with route and confidence · PRJNA725597_determinations.csv.gz (11.1 KB) — 1,873 evidence rows