Fecal Akkermansia and PD-1 blockade response in NSCLC, Paris
337 fecal metagenome samples from advanced non-small-cell lung cancer patients in Paris, France, treated with first- or second-line immune checkpoint inhibitors, in a case-control study validating Akkermansia muciniphila as a predictive biomarker. machine-written summary
338 samples · 338 runs · FR · Adult · 2021 · 3.25 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 3,034 sample values (age, bmi, collection date, country, latitude, location locality, location region, longitude) |
| ✓ Abstract / description | 338 sample values (subject id) |
| ✓ Full text | 177 sample values (health condition) · PMC10654443, PMC11480726, PMC11937697, PMC12654497, PMC13041121, PMC13091084, PMC13388844, PMC9330544 |
| ✓ Supplementary tables | 499 sample values (health condition, health condition detail) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 338 | 100% | ||||
| country | 338 | 100% | 338 | |||
| health_condition | 338 | 100% | 161 | 177 | ||
| subject_id | 338 | 100% | 338 | |||
| age_at_collection_days | 338 | 100% | 338 | |||
| collection_date | 338 | 100% | 338 | |||
| health_condition_detail | 338 | 100% | 338 | |||
| sex | 338 | 100% | 338 | |||
| detailed_location | 337 | 100% | ||||
| latitude | 337 | 100% | 337 | |||
| location_locality | 337 | 100% | 337 | |||
| location_region | 337 | 100% | 337 | |||
| longitude | 337 | 100% | 337 | |||
| bmi | 334 | 99% | 334 |
- Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer. 2022 PMID 35115705 PMC9330544 own_data
- Distinct gut virome profiles are associated with response to anti-PD-1 therapy in non-small cell lung cancer. 2026 PMID 41749306 PMC13041121 own_data
- A responder-informed gut microbial consortium enhances anti-PD-1 efficacy in a mouse cancer model. 2026 PMID 42007374 PMC13091084 own_data
- Gut microbial structural variation associates with immune checkpoint inhibitor response. 2023 PMID 37973916 PMC10654443 unsure
- Pangenomic analysis identifies correlations between <i>Akkermansia</i> species and subspecies and human health outcomes. 2024 PMID 39421249 PMC11480726 unsure
3 more
- Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types. 2025 PMID 40151642 PMC11937697
- Multi-Kingdom Gut Microbiome Interaction Characteristics Predict Immune Checkpoint Inhibitor Efficacy Across Pan-Cancer Cohorts. 2025 PMID 41304278 PMC12654497
- Enterotype-specific microbial biomarkers of immune checkpoint inhibitor response revealed by large-scale integrated metagenomic analysis. 2026 PMID 42189287 PMC13388844
Archive description
This study performed shotgun metagenomic microbiome profiling on 338 patients with NSCLC treated with first or second line immune checkpoint inhibitors to validate the prognostic significance of fecal Akkermansia muciniphila.
How this project entered the registry
Classified as human gut / stool / lower respiratory shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Intestinal Akkermansia muciniphila predicts”
- body site study.description · “prognostic significance of fecal Akkermansia muciniphila.”
- body site study.title · “advanced non-small cell lung cancer patients”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “69 (n=175/338)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN20549008 | age_at_collection_days | 22980.8 | R1 | 0.85 | sample.attr.host_age | 63 |
| SAMN20549105 | age_at_collection_days | 21915.0 | R1 | 0.85 | biosample.attribute:host_age | host_age: 60 |
| SAMN20549008 | bmi | 35.3 | R1 | 0.90 | sample.attr.host_body_mass_index | 35.3 |
| SAMN20549105 | bmi | 22.20 | R1 | 0.85 | biosample.attribute:host_body_mass_index | host_body_mass_index: 22.2 |
| SAMN20549008 | collection_date | 2017-03-20 | R1 | 0.90 | biosample.attribute:collection_date | 2017-03-20 |
| SAMN20549008 | country | FR | R1 | 0.90 | sample.attr.geo_loc_name | France: Paris |
| SAMN20549009 | health_condition | neurological_psychiatric | R2 | 0.60 | paper.supp.12967_2026_7900_MOESM1_ESM.xlsx[sample_group!Group] | PD |
| SAMN20549008 | health_condition | other_cancer | R3 | 0.70 | paper.fulltext.methods | histologically confirmed advanced NSCLC enrolled in a clinical study |
| SAMN20549008 | health_condition_detail | PR | R2 | 0.85 | paper.supp.12967_2026_7900_MOESM1_ESM.xlsx[sample_group!Group] | PR |
| SAMN20549008 | latitude | 48.7949 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN20549008 | location_locality | Paris | R1 | 0.85 | biosample.attribute:geo_loc_name | France: Paris |
| SAMN20549008 | location_region | Ile-de-France | R1 | 0.60 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN20549008 | longitude | 2.3486 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN20549008 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMN20549008 | subject_id | SAMN20549008 | R4 | 0.60 | design.one_sample_per_subject:abstract | performed shotgun-metagenomics-based microbiome profiling in a large cohort of patients with advanced NSCLC (n = 338) |
Sequencing
338 runs over 338 samples · mean 3.22 Gbp per run (median 3.25 Gbp, total 1,088.72 Gbp; 338 runs with a base count) · layout SINGLE 338 · platform ION_TORRENT 338 · models Ion Torrent Proton (338) · 0% of runs with a Sandpiper profile · first public 2021-11-04
Authors (60)
Mueller KD first · Panzetta ME · Davey L · McCann JR · Rawls JF · Flores GE · Valdivia RH last · Cai X first · Cho JY · Chen L · Liu Y · Ji F · Salgado K · Ge S · Yang D · Yu H · Shao J · Futreal PA · Sepesi B · Gibbons D · Chen Y · Wang G · Cheng C · Wu M · Zhang J · Hsiao A · Xia T last · Qiao T first · Zhu Z last · Liu Z first · Liu M · Chen H · Li S · Zheng N · Xing G · Zhang Y · Xu J · Li M · Xiao C · Lu T · Yan Q · Lei Z · Feng M · Li Y last · Candeliere F first · Busi E · Cerri S · Sola L · Lombardi M · Greco S · Pedroni S · Amaretti A · Raimondi S · Chiavelli C · Vitale MG · Bertolini F · Depenni R · Franchini G · Dominici M · Rossi M last
Downloads
PRJNA751792.csv.gz (11.8 KB) · parquet (87.4 KB) — all 338 samples, every field with route and confidence · PRJNA751792_determinations.csv.gz (28.2 KB) — 4,048 evidence rows