Fecal microbiome in colorectal adenoma and cancer, China
223 fecal metagenome samples from Beijing, China, comparing normal controls, advanced adenoma, and colorectal cancer patients to identify progressive gut microbiota gene markers; case-control design. machine-written summary
223 samples · 223 runs · CN · Age unknown · 2021 · 5.08 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,561 sample values (collection date, country, health condition, health condition detail, latitude, location locality, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 205 sample values (subject id) · PMC13281578, PMC9791776 |
| ✓ Supplementary tables | 223 sample values (bmi) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 89 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 223 | 100% | 223 | |||
| health_condition | 223 | 100% | 223 | |||
| subject_id | 205 | 92% | 205 | |||
| bmi | 223 | 100% | 223 | |||
| collection_date | 223 | 100% | 223 | |||
| detailed_location | 223 | 100% | ||||
| health_condition_detail | 223 | 100% | 223 | |||
| latitude | 223 | 100% | 223 | |||
| location_locality | 223 | 100% | 223 | |||
| longitude | 223 | 100% | 223 |
- A novel promising diagnosis model for colorectal advanced adenoma and carcinoma based on the progressive gut microbiota gene biomarkers. 2022 PMID 36572910 PMC9791776 unsure
- Gut fungal signatures in colorectal cancer and their potential for supporting diagnosis: a multi-cohort metagenomic analysis. 2026 PMID 42271362 PMC13281578 unsure
Archive description
Non-invasive progressive disease markers and indexes for colorectal adenoma and colorectal cancer based on intestinal microbiome
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.title · “advanced adenoma patients”
- body site study.description · “based on intestinal microbiome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN21015574 | bmi | 20.76 | R2 | 0.85 | paper.supp.13578_2022_940_MOESM2_ESM.xlsx[TableS1!BMI] | LZ-0048: 20.761245674740486 |
| SAMN21015574 | collection_date | 2017 | R1 | 0.90 | biosample.attribute:collection_date | 2017 |
| SAMN21015574 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Beijing |
| SAMN21015574 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:description | Normal Control |
| SAMN21015574 | health_condition_detail | Normal Control | R1 | 0.85 | biosample.attribute:description | Normal Control |
| SAMN21015574 | latitude | 39.9000 | R1 | 0.90 | biosample.attribute:lat_lon | 39.9 N 116.3 E |
| SAMN21015574 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Beijing |
| SAMN21015574 | longitude | 116.3000 | R1 | 0.90 | biosample.attribute:lat_lon | 39.9 N 116.3 E |
| SAMN21015574 | subject_id | SAMN21015574 | R3 | 0.75 | design.one_sample_per_subject:fulltext | each individual was asked to provide a stool sample before bowel preparation |
Sequencing
223 runs over 223 samples · mean 5.37 Gbp per run (median 5.08 Gbp, total 1,196.52 Gbp; 223 runs with a base count) · layout PAIRED 223 · platform BGISEQ 126, ILLUMINA 97 · models BGISEQ-500 (126), HiSeq X Ten (97) · 40% of runs with a Sandpiper profile · first public 2021-09-02 – 2021-09-03
Authors (32)
Xu J first · Zheng Z · Yang L · Li R · Ma X · Zhang J · Yin F · Liu L · Xu Q · Shen Q · Shen X · Wu C · Liu J · Qin N · Sheng J · Jin P · Zhang Z first · Lu T · Dong B · Zhang Y · Li S · Liu H · Li X · Guan T · Guo H · Yan Q · Lei Z · Yu X · Wang L · Kang J · Li L · Zhao D last
Downloads
PRJNA758208.csv.gz (7.4 KB) · parquet (80.6 KB) — all 223 samples, every field with route and confidence · PRJNA758208_determinations.csv.gz (17.4 KB) — 1,989 evidence rows