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PRJNA762199 SRP337805

Gut microbiota in depression vs healthy adults, Moscow

Metagenomic analysis of gut microbiota of people with depression disorders for determination of the composition of the marker genes.

74 gut metagenome samples from adults in Moscow, Russia, comparing individuals with depression disorders (36 samples) to healthy controls (38 samples) in a case-control study. machine-written summary

74 samples · 74 runs · RU · Adult · 2021 · 12.69 Gbp / sample

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Sources

✓Sequence archive 552✓Abstract / description 148○Full text✓Supplementary tables 29✓External resources 188–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave

✓ Sequence archive	552 sample values (collection date, country, health condition, health condition detail, latitude, location locality, location region, longitude)
✓ Abstract / description	148 sample values (location site, subject id)
○ Full text	read; no usable statement or table · PMC10671666, PMC11876151, PMC12174422, PMC13470864, PMC9209496, PMC9496097
✓ Supplementary tables	29 sample values (bmi)
✓ External resources	188 sample values (age, health condition, health condition detail, sex) · from GMrepo v3
– User contribution	nothing uploaded yet
– Human verified	not yet checked by a person · I checked this project — verify it

Samples at a glance

1 sampling locations · 1 country

Age

adult74

Condition

healthy_control38

neurological_psychiatric36

Sex

female37

male37

Country

RU74

Body site

primary74

Collected 2020–2021

Sequencing depth per sample · this project all projects

Community composition

Blautia_A 7.5%Faecalibacterium 7.2%Bifidobacterium 6.0%Roseburia 5.1%Prevotella 4.4%Bacteroides 4.1%Phocaeicola 3.0%Collinsella 2.9%Ruminococcoides 2.6%Alistipes 2.4%Mediterraneibacter 2.0%Gemmiger 2.0%not assigned to a genus 4.3%other genera 46.4%

Genera, mean relative abundance over 64 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage

field	samples	coverage	R1	R2	R4
age_category	74	100%
country	74	100%	74
health_condition	74	100%	36	38
subject_id	74	100%			74
age_at_collection_days	74	100%		74
collection_date	74	100%	74
detailed_location	74	100%
health_condition_detail	74	100%	36	38
latitude	74	100%	74
location_locality	74	100%	74
location_region	74	100%	74
location_site	74	100%			74
longitude	74	100%	74
sex	74	100%	36	38
bmi	29	39%		29

Papers (6)

Alterations of the Composition and Neurometabolic Profile of Human Gut Microbiota in Major Depressive Disorder. 2022 PMID 36140263 PMC9496097 own_data
Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder. 2025 PMID 40041700 PMC11876151 own_data
Deep embeddings to comprehend and visualize microbiome protein space. 2022 PMID 35725732 PMC9209496 unsure
Metagenomics reveals unique gut mycobiome biomarkers in major depressive disorder - a non-invasive method. 2025 PMID 40535544 PMC12174422 unsure
Gut microbial biomarkers for major depressive disorder: a cross-sectional study. 2026 PMID 42598412 PMC13470864 unsure

1 more

Unveiling the Connection between Microbiota and Depressive Disorder through Machine Learning 2023 PMC10671666

Details

Archive description

Gut metagenomes were isolated from patients with depression disorders and a group of healthy volunteers. The project is being conducted by Vavilov Institute of General Genetics RAS and Mental-health clinic No. 1 named after N.A. Alexeev

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
body site study.title · “Metagenomic analysis of gut microbiota of people”
body site study.description · “Gut metagenomes were isolated”
life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
life stage study.description · “group of healthy volunteers . The project”

Evidence examples (one per field × route)

sample	field	value	route	conf.	source	quote
SAMN21380290	age_at_collection_days	13879.5	R2	0.75	external.gmrepo source	host_age: 38.0
SAMN21380304	bmi	28.00	R2	0.85	paper.supp.Supplementary Table S1.xlsx[Supplementary Table S1!BMI, kg/m2]	BMI, kg/m2: 28
SAMN21380290	collection_date	2020-06-05	R1	0.90	biosample.attribute:collection_date	2020-06-05
SAMN21380290	country	RU	R1	0.90	sample.attr.geo_loc_name	Russia: Moscow
SAMN21380290	health_condition	neurological_psychiatric	R1	0.70	sample.name_rule:alias	PD_2
SAMN21380304	health_condition	healthy_control	R2	0.75	external.gmrepo source	phenotype: Health
SAMN21380290	health_condition_detail	PD	R1	0.70	sample.name_rule:alias	PD_2
SAMN21380304	health_condition_detail	Health	R2	0.75	external.gmrepo source	phenotype: Health
SAMN21380290	latitude	55.4500	R1	0.90	biosample.attribute:lat_lon	55.45 N 37.37 E
SAMN21380290	location_locality	Moscow	R1	0.85	biosample.attribute:geo_loc_name	Russia: Moscow
SAMN21380290	location_region	Moscow	R1	0.85	biosample.attribute:geo_loc_name	Russia: Moscow
SAMN21380290	location_site	Mental-health clinic No. 1 named after N.A. Alexeev	R4	0.40	ena.study_description	Mental-health clinic No. 1 named after N.A. Alexeev
SAMN21380290	longitude	37.3700	R1	0.90	biosample.attribute:lat_lon	55.45 N 37.37 E
SAMN21380290	sex	male	R1	0.70	sample.name_rule:description	Metagenome was isolated from feces of a patient with major depressive disorder (male, 38 years
SAMN21380304	sex	male	R2	0.75	external.gmrepo source	sex: male
SAMN21380290	subject_id	SAMN21380290	R4	0.60	design.one_sample_per_subject:abstract	We looked at the GM of 36 MDD patients, compared with that of 38 healthy volunteers

Sequencing

74 runs over 74 samples · mean 12.73 Gbp per run (median 12.69 Gbp, total 941.93 Gbp; 74 runs with a base count) · layout PAIRED 74 · platform ILLUMINA 74 · models HiSeq X Ten (74) · 86% of runs with a Sandpiper profile · first public 2021-09-21 – 2021-11-02

Authors (12)

Odrzywolek K first · Karwowska Z · Majta J · Byrski A · Milanowska-Zabel K · Kosciolek T last · Wang X first · Cao D · Zhang H · Chen W · Sun J · Hu H last

Downloads

PRJNA762199.csv.gz (3.5 KB) · parquet (75.8 KB) — all 74 samples, every field with route and confidence · PRJNA762199_determinations.csv.gz (9.1 KB) — 917 evidence rows

Samples (74 · every field this project has values for · hover a cell for its source)

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