Oral and gut microbiome in hypertension, Shanghai, China
180 samples (saliva, subgingival plaque, and feces) from hypertensive and control participants in Shanghai, China, examining oral-gut microbiota in hypertension using a case-control design. machine-written summary
180 samples · 180 runs · CN · Age unknown · 2022 · 13.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 720 sample values (collection date, country, location region, subject id) |
| ✓ Abstract / description | 120 sample values (health condition detail) |
| ✓ Full text | 180 sample values (location site) · PMC10180880, PMC10804974, PMC12172497, PMC9811375, PMC9927468 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 300 sample values (antibiotic exposure, health condition, health condition detail) · from BugSigDB, GMrepo v3 |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 56 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 180 | 100% | 180 | |||
| health_condition | 60 | 33% | 60 | |||
| subject_id | 180 | 100% | 180 | |||
| antibiotic_exposure | 180 | 100% | 180 | |||
| collection_date | 180 | 100% | 180 | |||
| detailed_location | 180 | 100% | ||||
| health_condition_detail | 180 | 100% | 60 | 120 | ||
| location_region | 180 | 100% | 180 | |||
| location_site | 180 | 100% | 180 |
- Characteristics and Correlations of the Oral and Gut Fungal Microbiome with Hypertension. 2023 PMID 36475759 PMC9927468 own_data
- Roles of oral microbiota and oral-gut microbial transmission in hypertension. 2023 PMID 36585105 PMC9811375 own_data
- Integrated Omic Analysis of Human Plasma Metabolites and Microbiota in a Hypertension Cohort. 2023 PMID 37432207 PMC10180880 own_data
- Alterations of oral and gut viromes in hypertension and/or periodontitis. 2024 PMID 38108668 PMC10804974 own_data
- Linking oral microbiota to periodontitis and hypertension unveils that Filifactor alocis aggravates hypertension via infiltration of interferon-γ+ T cells. 2025 PMID 40396735 PMC12172497 own_data
Archive description
investigate the oral and gut microbiome in hypertension
How this project entered the registry
Classified as human oral cavity / gut / stool shotgun DNA metagenome of age unknown by opus_adjudicated with confidence 0.75. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site study.title · “metagenome of human oral and gut microbiome”
- body site run.scientific_name · “human oral metagenome(120)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN21566083 | antibiotic_exposure | no | R2 | 0.60 | external.bugsigdb source | Antibiotics exclusion: 2 months |
| SAMN21566083 | collection_date | 2020-10-11 | R1 | 0.90 | biosample.attribute:collection_date | 2020-10-11T17:53:03Z |
| SAMN21566083 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Shanghai |
| SAMN21566203 | health_condition | cardiometabolic_other | R2 | 0.75 | external.gmrepo source | phenotype: Hypertension |
| SAMN21566203 | health_condition_detail | Hypertension | R2 | 0.75 | external.gmrepo source | phenotype: Hypertension |
| SAMN21566083 | health_condition_detail | mixed_case_control: HTN patients, PDHTN (hypertension with periodontitis), healthy controls | R4 | 0.50 | paper.abstract | 36 participants with HTN and 24 healthy controls |
| SAMN21566083 | location_region | Shanghai | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Shanghai |
| SAMN21566083 | location_site | Department of Cardiology, Shanghai Ninth People's Hospital | R3 | 0.70 | paper.fulltext.methods | Department of Cardiology at Shanghai Ninth People’s Hospital |
| SAMN21566083 | subject_id | 1 | R1 | 0.70 | sample.name_rule:alias | S1 |
Sequencing
180 runs over 180 samples · mean 22.43 Gbp per run (median 13.14 Gbp, total 4,037.18 Gbp; 180 runs with a base count) · layout PAIRED 180 · platform ILLUMINA 180 · models Illumina NovaSeq 6000 (180) · 90% of runs with a Sandpiper profile · first public 2022-04-04
Authors (31)
Chen BY first · Lin WZ · Li YL · Bi C · Du LJ · Liu Y · Zhou LJ · Liu T · Xu S · Shi CJ · Zhu H · Wang YL · Sun JY · Zhang WC · Zhang Z · Zhang HL · Zhu YQ · Duan SZ last · Lu HX · Wang YH · Feng Q · Chen FX · Wang CQ · Tonetti MS · Zhang H · Zhang J · Zhang ZY · Ye HL first · Zhi MF · Huang SJ · Meng XQ
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA765566.csv.gz (5.6 KB) · parquet (77.1 KB) — all 180 samples, every field with route and confidence · PRJNA765566_determinations.csv.gz (10.9 KB) — 1,320 evidence rows