Red Raspberry/FOS Diet Intervention in Prediabetes, Chicago
134 gut metagenome samples from adults with prediabetes/insulin resistance and metabolically healthy adults in Chicago, USA, in a randomized crossover trial of daily red raspberry supplementation alone or with fructo-oligosaccharide. machine-written summary
134 samples · 134 runs · US · Adult · 2021 · 1.18 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 804 sample values (collection date, country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen design crossover · population other_disease · Red raspberries 125g/day alone or with 8g FOS/day
“consuming RRB (125 g fresh equivalents) daily or RRB+8g FOS daily” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “Crossover trial: samples at baseline and end of each 4-week RRB or RRB+FOS period, separated by a 4-week washout” (time origin: intervention start).
Genera, mean relative abundance over 120 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 134 | 100% | ||||
| country | 134 | 100% | 134 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| collection_date | 134 | 100% | 134 | |||
| detailed_location | 134 | 100% | ||||
| latitude | 134 | 100% | 134 | |||
| location_locality | 134 | 100% | 134 | |||
| location_region | 134 | 100% | 134 | |||
| longitude | 134 | 100% | 134 |
- Red Raspberry and Fructo-Oligosaccharide Supplementation, Metabolic Biomarkers, and the Gut Microbiota in Adults with Prediabetes: A Randomized Crossover Clinical Trial. 2022 PMID 35421233 own_data
Archive description
This study aimed to investigate if supplementation with (poly)phenol-dense red raspberries (RRB) alone or with a fructo-oligosaccharide (FOS) prebiotic would improve biomarkers of cardio-metabolic risk in individuals with prediabetes and insulin resistance (PreDM-IR) and whether the effects are related to modulation of the gut microbiota.</p><p>Adults with PreDM-IR or that were metabolically healthy participated in a randomized crossover trial with two 4-week supplementation periods consuming RRB (125 g fresh equivalents) daily or RRB+8g FOS daily separated by a 4-week washout. The primary outcome variable was the composition of gut microbiota by shotgun sequencing assessed before and at the end of each supplementation period. Secondary outcomes were markers of glucose and lipid metabolism, anti-inflammatory status, and anthropometry.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.80. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
- life stage study.description · “Adults with PreDM-IR”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN21602553 | collection_date | 2017 | R1 | 0.90 | biosample.attribute:collection_date | 2017 |
| SAMN21602553 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Chicago |
| SAMN21602553 | latitude | 41.8700 | R1 | 0.90 | biosample.attribute:lat_lon | 41.87 N 87.62 W |
| SAMN21602553 | location_locality | Chicago | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Chicago |
| SAMN21602553 | location_region | Illinois | R1 | 0.60 | biosample.attribute:lat_lon | 41.87 N 87.62 W |
| SAMN21602553 | longitude | -87.6200 | R1 | 0.90 | biosample.attribute:lat_lon | 41.87 N 87.62 W |
Sequencing
134 runs over 134 samples · mean 1.23 Gbp per run (median 1.18 Gbp, total 164.16 Gbp; 134 runs with a base count) · layout PAIRED 134 · platform ILLUMINA 134 · models Illumina MiSeq (134) · 90% of runs with a Sandpiper profile · first public 2021-09-26
Authors (0)
No author record.
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA766048.csv.gz (3.9 KB) · parquet (74.6 KB) — all 134 samples, every field with route and confidence · PRJNA766048_determinations.csv.gz (4.8 KB) — 804 evidence rows