Gut microbiota and immunotherapy response, Seoul, Korea
2 samples from Seoul, Korea, examining gut microbiota (including the uncultured clade TANB77) in relation to immune checkpoint blockade therapy response; design classified as other. machine-written summary
2 samples · 2 runs · KR · Age unknown · 2022 · 8.45 Gbp / sample · cohort A conserved pilin from uncultured gut bacterial cl
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 14 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11680825 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 2 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 2 | 100% | 2 | |||
| health_condition | 2 | 100% | 2 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 2 | 100% | 2 | |||
| detailed_location | 2 | 100% | ||||
| health_condition_detail | 2 | 100% | 2 | |||
| latitude | 2 | 100% | 2 | |||
| location_region | 2 | 100% | 2 | |||
| longitude | 2 | 100% | 2 |
- A conserved pilin from uncultured gut bacterial clade TANB77 enhances cancer immunotherapy. 2024 PMID 39730328 PMC11680825 unsure
Archive description
An uncultured and distinct bacterial order, which is previously misclassified as Clostridium, is highly enriched in immunotherapy responders. This result is supported by the multi-cohort meta analysis and mouse experiments.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.
- host study.title · “Uncultivated human gut microbiota”
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human gut metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN22350889 | collection_date | 2020 | R1 | 0.90 | biosample.attribute:collection_date | 2020 |
| SAMN22350889 | country | KR | R1 | 0.90 | sample.attr.geo_loc_name | Korea: Seoul |
| SAMN22350889 | health_condition | other_cancer | R1 | 0.70 | sample.name_rule:alias | HighTANB77Donor |
| SAMN22350889 | health_condition_detail | HighTANB77Donor | R1 | 0.70 | sample.name_rule:alias | HighTANB77Donor |
| SAMN22350889 | latitude | 37.5600 | R1 | 0.90 | biosample.attribute:lat_lon | 37.56 N 126.94 E |
| SAMN22350889 | location_region | Seoul | R1 | 0.85 | biosample.attribute:geo_loc_name | Korea: Seoul |
| SAMN22350889 | longitude | 126.9400 | R1 | 0.90 | biosample.attribute:lat_lon | 37.56 N 126.94 E |
Sequencing
2 runs over 2 samples · mean 8.45 Gbp per run (median 8.45 Gbp, total 16.89 Gbp; 2 runs with a base count) · layout PAIRED 2 · platform ILLUMINA 2 · models Illumina HiSeq 4000 (2) · 100% of runs with a Sandpiper profile · first public 2022-03-03
Authors (23)
Kim CY first · Park DJ · Ahn BC · Baek S · Hong MH · Nguyen LT · Hwang SH · Kim N · Podlesny D · Orakov A · Schudoma C · Robbani SM · Shim HS · Yoon HI · Lee CY · Park SY · Yong D · Han M · Bork P · Kim BC · Ha SJ · Kim HR · Lee I last
Downloads
PRJNA771940.csv.gz (935 B) · parquet (69.5 KB) — all 2 samples, every field with route and confidence · PRJNA771940_determinations.csv.gz (692 B) — 14 evidence rows