Gut microbiota and ADT response in prostate cancer, Paris
78 fecal samples from prostate cancer patients (mostly elderly adults) in Paris, France, comparing hormone-sensitive versus castration-resistant disease to study gut microbiota's role in androgen deprivation therapy efficacy; case-control design. machine-written summary
78 samples · 78 runs · FR · Adult · 2022 · 7.05 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 856 sample values (age, collection date, country, health condition, health condition detail, latitude, location locality, location region) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 78 sample values (sex) · PMC8928383 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
19 of 52 people sampled more than once (43 samples; median 2, up to 3 per person). Schedule stated by the source: “stool at baseline (pre-ADT) and 4–6 months after ADT (post-ADT)” (time origin: intervention_start); stated follow-up 6 mo.
Genera, mean relative abundance over 70 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 78 | 100% | ||||
| country | 78 | 100% | 78 | |||
| health_condition | 78 | 100% | 78 | |||
| subject_id | 76 | 97% | 76 | |||
| age_at_collection_days | 78 | 100% | 78 | |||
| collection_date | 78 | 100% | 78 | |||
| detailed_location | 78 | 100% | ||||
| health_condition_detail | 78 | 100% | 78 | |||
| latitude | 78 | 100% | 78 | |||
| location_locality | 78 | 100% | 78 | |||
| location_region | 78 | 100% | 78 | |||
| longitude | 78 | 100% | 78 | |||
| sex | 78 | 100% | 78 | |||
| timepoint_label | 78 | 100% | 78 |
- Immune system and intestinal microbiota determine efficacy of androgen deprivation therapy against prostate cancer. 2022 PMID 35296557 PMC8928383 own_data
Archive description
We investigated the contribution of the intestinal microbiota to the efficacy of ADT in faecal specimens from prostate cancer patients.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Immune system and intestinal microbiota determine efficacy”
- body site study.description · “contribution of the intestinal microbiota to the”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “71 (n=53/78)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN24344450 | age_at_collection_days | 25932.8 | R1 | 0.70 | sample.attr.host_age | 71 |
| SAMN24344450 | collection_date | 2017-03-20 | R1 | 0.90 | biosample.attribute:collection_date | 2017-03-20 |
| SAMN24344450 | country | FR | R1 | 0.90 | sample.attr.geo_loc_name | France: Paris |
| SAMN24344450 | health_condition | other_cancer | R1 | 0.80 | biosample_attr | PCa_CRPC |
| SAMN24344480 | health_condition | other_cancer | R1 | 0.85 | biosample.attribute:group | group: PCa_HS |
| SAMN24344450 | health_condition_detail | PCa_CRPC | R1 | 0.85 | biosample.attribute:group | group: PCa_CRPC |
| SAMN24344450 | latitude | 48.7949 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN24344450 | location_locality | Paris | R1 | 0.85 | biosample.attribute:geo_loc_name | France: Paris |
| SAMN24344450 | location_region | Ile-de-France | R1 | 0.60 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN24344450 | longitude | 2.3486 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79488039 N 2.34860488 E |
| SAMN24344450 | sex | male | R3 | 0.70 | paper.fulltext.abstract | 65 HSPC and CRPC patients |
| SAMN24344450 | subject_id | Pr_01_II | R1 | 0.70 | sample.name_rule:alias | Pr_01_II_V3 |
| SAMN24344450 | timepoint_label | V3 | R1 | 0.85 | biosample.attribute:adt_duration | adt_duration: V3 |
Sequencing
78 runs over 78 samples · mean 11.59 Gbp per run (median 7.05 Gbp, total 903.83 Gbp; 78 runs with a base count) · layout PAIRED 78 · platform ILLUMINA 78 · models Illumina NovaSeq 6000 (78) · 90% of runs with a Sandpiper profile · first public 2022-03-20
Authors (37)
Terrisse S first · Goubet AG · Ueda K · Thomas AM · Quiniou V · Thelemaque C · Dunsmore G · Clave E · Gamat-Huber M · Yonekura S · Ferrere G · Rauber C · Pham HP · Fahrner JE · Pizzato E · Ly P · Fidelle M · Mazzenga M · Costa Silva CA · Armanini F · Pinto F · Asnicar F · Daillère R · Derosa L · Richard C · Blanchard P · Routy B · Culine S · Opolon P · Silvin A · Ginhoux F · Toubert A · Segata N · McNeel DG · Fizazi K · Kroemer G · Zitvogel L last
Downloads
PRJNA791751.csv.gz (3.4 KB) · parquet (74.7 KB) — all 78 samples, every field with route and confidence · PRJNA791751_determinations.csv.gz (7.6 KB) — 934 evidence rows