Gut microbiota in T2DM patients on GLP-1 therapy, Shantou
36 stool samples from middle-aged and elderly type 2 diabetes patients in Shantou, China, collected at weeks 0, 4, and 8 of GLP-1 (Loxenatide) treatment in an intervention study. machine-written summary
36 samples · 36 runs · CN · Adult · 2022 · 9.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 252 sample values (country, latitude, location locality, location region, longitude, subject id, timepoint) |
| ✓ Abstract / description | 36 sample values (location site) |
| ✓ Full text | 108 sample values (collection date, health condition, health condition detail) · PMC9240776 |
| ✓ Supplementary tables | 72 sample values (age, bmi) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal
12 of 12 people sampled more than once (36 samples; median 3, up to 3 per person) · follow-up median 56 d (max 56 d) · median interval between samples 28 d (time from timepoint numbers, unit from the stated sampling schedule). Schedule stated by the source: “stool at week 0, 4, and 8 of GLP-1 treatment” (time origin: intervention_start); stated follow-up 56 d.
Each row is one person (12 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 33 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 36 | 100% | ||||
| country | 36 | 100% | 36 | |||
| health_condition | 36 | 100% | 36 | |||
| subject_id | 36 | 100% | 36 | |||
| age_at_collection_days | 36 | 100% | 36 | |||
| bmi | 36 | 100% | 36 | |||
| collection_date | 36 | 100% | 36 | |||
| detailed_location | 36 | 100% | ||||
| health_condition_detail | 36 | 100% | 36 | |||
| latitude | 36 | 100% | 36 | |||
| location_locality | 36 | 100% | 36 | |||
| location_region | 36 | 100% | 36 | |||
| location_site | 36 | 100% | 36 | |||
| longitude | 36 | 100% | 36 | |||
| timepoint_label | 36 | 100% | 36 |
- Polyethylene Glycol Loxenatide Injection (GLP-1) Protects Vascular Endothelial Cell Function in Middle-Aged and Elderly Patients With Type 2 Diabetes by Regulating Gut Microbiota. 2022 PMID 35782875 PMC9240776 own_data
Archive description
GLP-1 improves endothelial cell function indicators in middle-aged and elderly diabetic patients, which may be related to its alteration of the population numbers of gut microbiota.We conduct this project.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “of T2DM human gut microbes treated with”
- body site study.description · “population numbers of gut microbiota.We conduct this”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “in middle-aged and elderly diabetic patients, which”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN26182850 | age_at_collection_days | 29220 | R2 | 0.85 | paper.supp.Table1.XLSX[Sheet1!Age] | 80 |
| SAMN26182850 | bmi | 18.6 | R2 | 0.85 | paper.supp.Table1.XLSX[Sheet1!BMI(kg/m2)] | 18.61 |
| SAMN26182850 | collection_date | 2019-06/2019-11 | R3 | 0.70 | paper.fulltext.abstract | from June 2019 to November 2019 |
| SAMN26182850 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Shantou |
| SAMN26182850 | health_condition | type2_diabetes | R3 | 0.70 | paper.fulltext.abstract | newly diagnosed or poorly controlled type 2 diabetes |
| SAMN26182850 | health_condition_detail | newly diagnosed or poorly controlled type 2 diabetes mellitus (T2DM) | R3 | 0.70 | paper.fulltext.abstract | newly diagnosed or poorly controlled type 2 diabetes |
| SAMN26182850 | latitude | 23.3700 | R1 | 0.90 | biosample.attribute:lat_lon | 23.37 N 116.72 E |
| SAMN26182850 | location_locality | Shantou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Shantou |
| SAMN26182850 | location_region | Guangdong | R1 | 0.60 | biosample.attribute:lat_lon | 23.37 N 116.72 E |
| SAMN26182850 | location_site | Longhu People's Hospital / Shantou Central Hospital | R4 | 0.50 | paper.abstract | Longhu People's Hospital and Shantou Central Hospital |
| SAMN26182850 | longitude | 116.7200 | R1 | 0.90 | biosample.attribute:lat_lon | 23.37 N 116.72 E |
| SAMN26182850 | subject_id | 1 | R1 | 0.70 | sample.name_rule:alias | P1_0 |
| SAMN26182850 | timepoint_label | 0 | R1 | 0.70 | sample.name_rule:alias | P1_0 |
Sequencing
36 runs over 36 samples · mean 9.19 Gbp per run (median 9.14 Gbp, total 330.73 Gbp; 36 runs with a base count) · layout PAIRED 36 · platform ILLUMINA 36 · models Illumina NovaSeq 6000 (36) · 92% of runs with a Sandpiper profile · first public 2022-04-04
Authors (13)
Chen F first · He L · Li J · Yang S · Zhang B · Zhu D · Wu Z · Zhang S · Hou D · Ouyang C · Yi J · Xiao C · Hou K last
Downloads
PRJNA809514.csv.gz (2.2 KB) · parquet (73.2 KB) — all 36 samples, every field with route and confidence · PRJNA809514_determinations.csv.gz (4.1 KB) — 468 evidence rows