FMT during pregnancy: strain transfer to infant, Denmark
12 samples from Denmark, case series tracking strain transmission from donor to mother to infant after fecal microbiota transplantation (FMT) during pregnancy; 3 samples from infants. machine-written summary
12 samples · 12 runs · DK · Infant / toddler · 2022 · 8.28 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 57 sample values (collection date, country, family role, health condition, health condition detail, intervention, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 8 sample values (delivery mode, feeding mode, preterm status) · PMC9647999 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design single_arm_before_after · population gi_infection_or_diarrhoea · FMT via colonoscopy for CDI during pregnancy
“treated with FMT via colonoscopy” — abstract:36352460 (study level; per-sample arms are in the intervention column below)
longitudinalFMT donor → recipientmother–infant
2 of 4 people sampled more than once (10 samples; median 5, up to 7 per person) · follow-up median 9 mo (max 12 mo) · median interval between samples 49 d (time from collection dates). Schedule stated by the source: “Mother at pregnancy weeks 1,15,22; infant at 0,3,6 months after birth”.
Each row is one person (2 shown); dots are samples at days since that person's first sample.
FMT case: donor -> pregnant patient (mother) -> her infant; plus 1 unrelated donor.
motherchilddonor · circles are people (pale = no sequenced sample), arrows run donor → recipient and parent → child, curved lines join twins, partners and siblings, squares are shared settings or families without recorded roles. Shown: 1 linked group from explicit relations. 4 people in the project overall.
Genera, mean relative abundance over 12 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 3 | 25% | ||||
| country | 12 | 100% | 12 | |||
| health_condition | 2 | 17% | 2 | |||
| subject_id | 12 | 100% | 12 | |||
| collection_date | 12 | 100% | 12 | |||
| family_role | 10 | 83% | 10 | |||
| intervention | 7 | 58% | 7 | |||
| delivery_mode | 3 | 25% | 3 | |||
| preterm_status | 3 | 25% | 3 | |||
| feeding_mode | 2 | 17% | 2 | |||
| health_condition_detail | 2 | 17% | 2 |
- Cross-generational bacterial strain transfer to an infant after fecal microbiota transplantation to a pregnant patient: a case report. PMID 36352460 PMC9647999 curated
Archive description
We aim to assess if fecal microbiota transplantation (FMT) during pregnancy is effective and safe. Furthermore, we aim to track the strain transmission from the donor, to the mother, and further to the infant.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “to infant after fecal microbiota transplantation of”
- body site study.description · “to assess if fecal microbiota transplantation (FMT)”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “from donor to infant after fecal microbiota”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN26419854 | collection_date | 2018-07-03 | R1 | 0.85 | biosample.attribute:collection_date | 2018-07-03 |
| SAMN26419854 | country | DK | R1 | 0.90 | biosample_attr | Denmark |
| SAMN26419861 | delivery_mode | vaginal | R3 | 0.60 | paper.fulltext.abstract | gave vaginal birth at term |
| SAMN26419855 | family_role | mother | R1 | 0.60 | biosample.attribute:individual | individual: Patient |
| SAMN26419861 | feeding_mode | exclusive_breast | R3 | 0.60 | paper.fulltext.results | exclusively breastfed until 4 months of age |
| SAMN26419854 | health_condition | healthy_control | R1 | 0.85 | biosample.attribute:individual | Donor |
| SAMN26419854 | health_condition_detail | Donor | R1 | 0.85 | biosample.attribute:individual | Donor |
| SAMN26419855 | intervention | fmt | R1 | 0.85 | biosample.attribute:individual | Patient |
| SAMN26419861 | preterm_status | term | R3 | 0.60 | paper.fulltext.abstract | born at term, 26 weeks after |
| SAMN26419854 | subject_id | Donor | R1 | 0.85 | biosample.attribute:individual | Donor |
Sequencing
12 runs over 12 samples · mean 9.00 Gbp per run (median 8.28 Gbp, total 107.96 Gbp; 12 runs with a base count) · layout PAIRED 12 · platform ILLUMINA 12 · models Illumina HiSeq 2500 (12) · 100% of runs with a Sandpiper profile · first public 2022-06-30
Authors (11)
Wei S first · Jespersen ML · Baunwall SMD · Myers PN · Smith EM · Dahlerup JF · Rasmussen S · Nielsen HB · Licht TR · Bahl MI · Hvas CL last
Downloads
PRJNA812583.csv.gz (1.3 KB) · parquet (70.5 KB) — all 12 samples, every field with route and confidence · PRJNA812583_determinations.csv.gz (1.3 KB) — 65 evidence rows