Oligosaccharide and probiotic intervention in healthy adults
377 gut microbiome samples from healthy adult volunteers in an intervention study evaluating a complex oligosaccharide with and without a probiotic. machine-written summary
377 samples · 377 runs · Adult · 2022 · 0.68 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,508 sample values (age, sex, subject id, timepoint) |
| ✓ Abstract / description | 754 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Prebiotic / dietary fibre supplement Probiotic (live microorganisms; single strain or mixture) design randomized_controlled_trial · population healthy_control · Complex oligosaccharide with/without probiotic in healthy volunteers
“synergy of the use of a complex oligosaccharide with and without a” — bioproject.description (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
58 of 58 people sampled more than once (377 samples; median 6, up to 11 per person).
Genera, mean relative abundance over 333 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 377 | 100% | ||||
| country | 0 | 0% | ||||
| health_condition | 377 | 100% | 377 | |||
| subject_id | 377 | 100% | 377 | |||
| age_at_collection_days | 377 | 100% | 377 | |||
| health_condition_detail | 377 | 100% | 377 | |||
| sex | 377 | 100% | 377 | |||
| timepoint_label | 377 | 100% | 377 |
- Dosing a synbiotic of human milk oligosaccharides and B. infantis leads to reversible engraftment in healthy adult microbiomes without antibiotics. 2022 PMID 35504279 own_data
Archive description
The study evaluates the synergy of the use of a complex oligosaccharide with and without a probiotic on the human microbiome in healthy volunteers.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.62. Assay shotgun_dna.
- host study.description · “human microbiome in healthy volunteers”
- body site sample.attr.tissue · “stool (n=377/377)”
- life stage study.description · “healthy volunteers”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN26544945 | age_at_collection_days | 9131.0 | R1 | 0.85 | sample.attr.age | 25 |
| SAMN26544945 | health_condition | healthy_control | R4 | 0.50 | paper.abstract.abstract | engrafts into healthy adult microbiomes in an HMO-dependent manner |
| SAMN26544945 | health_condition_detail | healthy volunteers | R4 | 0.50 | paper.abstract.abstract | engrafts into healthy adult microbiomes in an HMO-dependent manner |
| SAMN26544945 | sex | male | R1 | 0.90 | sample.attr.sex | male |
| SAMN26544945 | subject_id | 13 | R1 | 0.85 | biosample.attribute:isolate | 13 |
| SAMN26544945 | timepoint_label | 1 | R1 | 0.85 | sample.attr.day_of_study | 1 |
Sequencing
377 runs over 377 samples · mean 0.73 Gbp per run (median 0.68 Gbp, total 276.33 Gbp; 377 runs with a base count) · layout PAIRED 377 · platform ILLUMINA 377 · models Illumina NovaSeq 6000 (377) · 88% of runs with a Sandpiper profile · first public 2022-04-26
Authors (0)
No author record.
Downloads
PRJNA814303.csv.gz (9.5 KB) · parquet (82.2 KB) — all 377 samples, every field with route and confidence · PRJNA814303_determinations.csv.gz (11.9 KB) — 2,262 evidence rows