FMT for type 1 diabetes in adolescents, Shantou, China
38 fecal metagenome samples from adolescent patients with type 1 diabetes in Shantou, China, studying fecal microbiota transplantation as an intervention over up to 30 weeks of follow-up. machine-written summary
38 samples · 38 runs · CN · Adult · 2022 · 9.14 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 190 sample values (country, latitude, location locality, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 152 sample values (antibiotic exposure, health condition, health condition detail, sex) · PMC9414079 |
| ✓ Supplementary tables | 42 sample values (age, collection date, intervention, subject id, timepoint) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design single_arm_before_after · population type1_diabetes · One to three rounds of fecal microbiota transplantation
“received one to three rounds of normal fecal microbiota transplants” — abstract:36032108 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
1 of 1 people sampled more than once (10 samples; median 10, up to 10 per person). Schedule stated by the source: “Stool collected before/after FMT at day 1, week 6, and week 8, with 30-week clinical follow-up” (time origin: intervention_start); stated follow-up 7 mo.
Genera, mean relative abundance over 37 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 38 | 100% | ||||
| country | 38 | 100% | 38 | |||
| health_condition | 38 | 100% | 38 | |||
| subject_id | 10 | 26% | 10 | |||
| antibiotic_exposure | 38 | 100% | 38 | |||
| detailed_location | 38 | 100% | ||||
| health_condition_detail | 38 | 100% | 38 | |||
| latitude | 38 | 100% | 38 | |||
| location_locality | 38 | 100% | 38 | |||
| location_region | 38 | 100% | 38 | |||
| longitude | 38 | 100% | 38 | |||
| sex | 38 | 100% | 38 | |||
| age_at_collection_days | 10 | 26% | 10 | |||
| intervention | 8 | 21% | 8 | |||
| collection_date | 7 | 18% | 7 | |||
| timepoint_label | 7 | 18% | 7 |
- Fecal microbiota transplantation treatment of autoimmune-mediated type 1 diabetes mellitus. 2022 PMID 36032108 PMC9414079 own_data
Archive description
we conducted an experimental treatment study in two adolescent patients diagnosed with autoimmune type 1 diabetes for one year
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and adolescent by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Fecal Microbiota Transplantation Treatment”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “study in two adolescent patients diagnosed with”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN27962955 | age_at_collection_days | 4383 | R2 | 0.80 | paper.supp.Table_4.xlsx[Sheet1!Age] | 12 |
| SAMN27962951 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | treated with other hormones or antibiotics in the past three months |
| SAMN27962955 | collection_date | 2021-10-03 | R2 | 0.80 | paper.supp.Table_4.xlsx[Sheet1!Sample date] | 2021-10-03 |
| SAMN27962951 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Shantou |
| SAMN27962951 | health_condition | type1_diabetes | R3 | 0.70 | paper.fulltext.abstract | two adolescent patients diagnosed with autoimmune T1DM |
| SAMN27962951 | health_condition_detail | autoimmune-mediated Type 1 Diabetes Mellitus (T1DM) | R3 | 0.70 | paper.fulltext.abstract | two adolescent patients diagnosed with autoimmune T1DM |
| SAMN27962955 | intervention | fmt | R2 | 0.80 | paper.supp.Table_4.xlsx[Sheet1!Group] | FMT |
| SAMN27962951 | latitude | 23.3500 | R1 | 0.90 | biosample.attribute:lat_lon | 23.35 N 116.68 E |
| SAMN27962951 | location_locality | Shantou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Shantou |
| SAMN27962951 | location_region | Guangdong | R1 | 0.60 | biosample.attribute:lat_lon | 23.35 N 116.68 E |
| SAMN27962951 | longitude | 116.6800 | R1 | 0.90 | biosample.attribute:lat_lon | 23.35 N 116.68 E |
| SAMN27962951 | sex | male | R3 | 0.70 | paper.fulltext.methods | Patient 1 was a 15-year-old male |
| SAMN27962955 | subject_id | Patient2 | R2 | 0.80 | paper.supp.Table_4.xlsx[Sheet1!Name] | Patient2 |
| SAMN27962955 | timepoint_label | W10 | R2 | 0.80 | paper.supp.Table_4.xlsx[Sheet1!visit-time / week] | W10 |
Sequencing
38 runs over 38 samples · mean 8.80 Gbp per run (median 9.14 Gbp, total 334.37 Gbp; 38 runs with a base count) · layout PAIRED 38 · platform ILLUMINA 38 · models Illumina NovaSeq 6000 (38) · 97% of runs with a Sandpiper profile · first public 2022-06-20 – 2022-06-21
Authors (11)
He L first · Chen R · Zhang B · Zhang S · Khan BA · Zhu D · Wu Z · Xiao C · Chen B · Chen F · Hou K last
Downloads
PRJNA833152.csv.gz (2.0 KB) · parquet (72.5 KB) — all 38 samples, every field with route and confidence · PRJNA833152_determinations.csv.gz (3.3 KB) — 384 evidence rows