Infant gut and breast milk microbiota, antibiotics, India
22 samples from India (Thrissur and Trivandrum) in a longitudinal cohort study examining maternal postpartum antibiotic prophylaxis and its impact on infant gut and breast milk microbiota. machine-written summary
22 samples · 22 runs · IN · Infant / toddler · 2023 · 7.02 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 88 sample values (antibiotic exposure, collection date, country, subject id) |
| ✓ Abstract / description | 20 sample values (maternal antibiotics) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Antibiotic given as the study intervention (incl. eradication therapy design observational_with_procedure · population pregnancy_postpartum · Maternal postpartum antibiotic prophylaxis
“maternal postpartum antibiotic prophylaxis” — bioproject.description (study level; per-sample arms are in the intervention column below)
mother–infant — not resolved
20 infant fecal samples + 2 maternal breastmilk samples; likely mother-infant linkage but no explicit dyad count given..
Genera, mean relative abundance over 17 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 22 | 100% | 22 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 22 | 100% | 22 | |||
| antibiotic_exposure | 22 | 100% | 22 | |||
| collection_date | 22 | 100% | 22 | |||
| maternal_antibiotics | 20 | 91% | 20 |
Archive description
The present work studies the impact of maternal postpartum antibiotic prophylaxis on Infant gut and breastmilk microbiota in order to highlight the importance of judicious use of antibiotics in the postpartum period. This would result in a more balance infant gut microbiome and reduce the threat of antimicrobial resistance.
How this project entered the registry
Classified as human gut / stool / human milk shotgun DNA metagenome of infant / toddler and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “analysis of Infant gut and breast milk”
- body site study.description · “prophylaxis on Infant gut and breastmilk microbiota”
- body site study.title · “Infant gut and breast milk microbiota”
- body site study.description · “Infant gut and breastmilk microbiota in order”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.title · “metagenome analysis of Infant gut and breast”
- life stage study.description · “the impact of maternal postpartum antibiotic prophylaxis”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN28100429 | antibiotic_exposure | yes | R1 | 0.70 | biosample.attribute:env_broad_scale | Infant gut microbiome exposed to Moxclav antibiotic |
| SAMN28100429 | collection_date | 2020-01-15 | R1 | 0.85 | biosample.attribute:collection_date | collection_date: 2020-01-15 |
| SAMN28100429 | country | IN | R1 | 0.90 | biosample_attr | India: Trivandrum |
| SAMN28100429 | maternal_antibiotics | yes | R4 | 0.50 | study.description | impact of maternal postpartum antibiotic prophylaxis |
| SAMN28100429 | subject_id | Infant Ab1 | R1 | 0.50 | biosample_attr | Infant Ab1 |
Sequencing
22 runs over 22 samples · mean 8.19 Gbp per run (median 7.02 Gbp, total 180.14 Gbp; 22 runs with a base count) · layout PAIRED 22 · platform ILLUMINA 22 · models Illumina HiSeq X (22) · 86% of runs with a Sandpiper profile · first public 2023-06-05
Authors (0)
No author record.
Downloads
PRJNA835321.csv.gz (1.7 KB) · parquet (70.4 KB) — all 22 samples, every field with route and confidence · PRJNA835321_determinations.csv.gz (1.7 KB) — 108 evidence rows