Gestational diabetes diet trial, maternal microbiome
131 samples from a randomized trial in Colorado, USA, comparing a higher complex carbohydrate/lower fat diet vs. a conventional lower carbohydrate diet in women with gestational diabetes mellitus. machine-written summary
131 samples · 391 runs · US · Infant / toddler · 2022 · 9.29 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 441 sample values (collection date, country, subject id, timepoint) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC10269646, PMC9366142 |
| ✓ Supplementary tables | 63 sample values (subject id) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Controlled / prescribed diet or feeding regimen design randomized_controlled_trial · population pregnancy_postpartum · CHOICE higher-complex-carb vs conventional diet in GDM pregnancy
“randomized, controlled trial in diet-controlled women with GDM” — abstract:35966074 (study level; per-sample arms are in the intervention column below)
longitudinalmother–infant — not resolved
34 of 97 people sampled more than once (68 samples; median 2, up to 2 per person) · follow-up median 34 d (max 49 d) · median interval between samples 34 d (time from collection dates). Schedule stated by the source: “mother at 30W, 37W gestation; infant at 2W, 2M, 4to5M” (time origin: other:gestation/birth); stated follow-up 12 mo.
Each row is one person (34 shown); dots are samples at days since that person's first sample.
Mothers (stool at 30 and 37 wk gestation) and infants (2 wk, 2 mo, 4–5 mo) coded CHOnn_M / CHOnn_B; dyad links by code not committed.
Genera, mean relative abundance over 131 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 131 | 100% | 131 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 131 | 100% | 68 | 63 | ||
| collection_date | 131 | 100% | 131 | |||
| timepoint_label | 111 | 85% | 111 |
- A maternal higher-complex carbohydrate diet increases bifidobacteria and alters early life acquisition of the infant microbiome in women with gestational diabetes mellitus. PMID 35966074 PMC9366142 curated
- Exploring Molecular Interactions between Human Milk Hormone Insulin and Bifidobacteria. PMID 37191543 PMC10269646 curated
Archive description
The rapidly rising risk of gestational diabetes pregnant women demands that an effective diet strategy be developed due to the high risk of fetal overgrowth, which places the newborn at increased risk for childhood obesity and metabolic syndrome. The aims of this randomized clinical trial are to compare the effects of an 8-wk isocaloric higher complex carbohydrate/lower fat diet vs. a conventional lower carbohydrate (higher fat) diet on glycemic and lipid profiles, maternal insulin resistance, placenta nutrient transporters, the maternal microbiome, neonatal intrahepatic fat, and neonatal total adiposity (primary outcome). The investigators will then follow the infants for 1-yr and measure maternal breast milk and infant microbiome composition to observe if they impact net fat mass gain differently in infants exposed to one diet vs. the other. Identifying a diet for gestational diabetes mellitus women that can effectively alter maternal/fetal metabolism is critical to reducing short- and long-term metabolic risk in this growing cohort of mothers and infants and has the potential to be applicable to overweight/obese pregnant women.
How this project entered the registry
Classified as human gut / stool / human milk / blood / tissue / internal fluids shotgun DNA metagenome of infant / toddler and neonate and child and adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site external_curation.infant_catalog · “infant triage verdict include (gut/stool scope)”
- body site study.description · “and measure maternal breast milk and infant microbiome”
- body site study.description · “maternal insulin resistance, placenta nutrient transporters, the”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “then follow the infants for 1-yr and”
- life stage study.description · “which places the newborn at increased risk”
- life stage study.description · “increased risk for childhood obesity and metabolic”
- life stage study.description · “of gestational diabetes pregnant women demands that an”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN28861863 | collection_date | 2015-08-04 | R1 | 0.85 | biosample.attribute:collection_date | 2015-08-04 |
| SAMN28861863 | country | US | R1 | 0.90 | biosample_attr | USA: Colorado |
| SAMN28861863 | subject_id | CHO01_M | R1 | 0.70 | sample.name_rule:library_name | CHO01_M_30W_rep1 |
| SAMN28861931 | subject_id | SRR19635036 | R2 | 0.75 | paper.supp.table | Sample=SRR19635036 |
| SAMN28861863 | timepoint_label | 30W | R1 | 0.70 | run.library_name | CHO01_M_30W_rep1 |
Sequencing
391 runs over 131 samples · mean 3.61 Gbp per run (median 2.80 Gbp, total 1,409.74 Gbp; 391 runs with a base count) · layout PAIRED 391 · platform ILLUMINA 391 · models Illumina NovaSeq 6000 (391) · 94% of runs with a Sandpiper profile · first public 2022-07-26
Authors (18)
Sugino KY first · Hernandez TL · Barbour LA · Kofonow JM · Frank DN · Friedman JE last · Rizzo SM first · Alessandri G · Lugli GA · Fontana F · Tarracchini C · Mancabelli L · Viappiani A · Bianchi MG · Bussolati O · van Sinderen D · Ventura M · Turroni F last
Help complete this project
2 of the 4 core fields are below 50% coverage: age_category, health_condition. Share metadata
Downloads
PRJNA845806.csv.gz (5.3 KB) · parquet (76.5 KB) — all 131 samples, every field with route and confidence · PRJNA845806_determinations.csv.gz (6.0 KB) — 504 evidence rows