Gut microbiome in heart transplant recipients, Chicago
Cross-sectional study of 48 fecal samples from heart transplant recipients in Chicago, IL, examining gut microbiome composition and microbial metabolite production in relation to transplantation. machine-written summary
48 samples · 48 runs · US · Adult · 2022 · 1.91 Gbp / sample · cohort Fecal Butyrate and Deoxycholic Acid Concentrations
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 528 sample values (age, bmi, collection date, country, health condition, health condition detail, latitude, location locality) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC11235359, PMC12788677, PMC13123906 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
longitudinal — not resolved
Schedule stated by the source: “Subset of 17 HT recipients had paired pre- and post-HT stool samples, median 5 days before and 10 days after HT; others single timepoint within 14 days pre/post HT.” (time origin: transplant).
Genera, mean relative abundance over 46 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 48 | 100% | ||||
| country | 48 | 100% | 48 | |||
| health_condition | 48 | 100% | 48 | |||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 48 | 100% | 48 | |||
| bmi | 48 | 100% | 48 | |||
| collection_date | 48 | 100% | 48 | |||
| detailed_location | 48 | 100% | ||||
| health_condition_detail | 48 | 100% | 48 | |||
| latitude | 48 | 100% | 48 | |||
| location_locality | 48 | 100% | 48 | |||
| location_region | 48 | 100% | 48 | |||
| longitude | 48 | 100% | 48 | |||
| sex | 48 | 100% | 48 |
- Reduced immunomodulatory metabolite concentrations in peri-transplant fecal samples from heart allograft recipients. 2023 PMID 38993864 PMC11235359 own_data
- Fecal butyrate and deoxycholic acid quantitation for rapid assessment of the gut microbiome. 2026 PMID 41511994 PMC12788677 unsure
- The intestinal microbiota impacts nutritional immunity and resistance to <i>Acinetobacter baumannii</i> pneumonia. 2026 PMID 42012958 PMC13123906 unsure
Archive description
In order to improve our understanding of de novo DSA production, we aim to examine the interaction between the microbiome and HT. The role of the gut microbiome has been understudied in solid organ, particularly HT, with nearly no studies examining its role in human HT recipients.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.60. Assay shotgun_dna.
- host run.scientific_name · “human gut metagenome”
- body site study.description · “the gut microbiome has been understudied”
- life stage sample.attr.host_age · “50 (n=35/48)”
- life stage sample.attr.host_age · “65 (n=9/48)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN28887788 | age_at_collection_days | 14239.8 | R1 | 0.85 | sample.attr.host_age | 39 |
| SAMN28887788 | bmi | 23.8 | R1 | 0.90 | sample.attr.host_body_mass_index | 23.8 |
| SAMN28887788 | collection_date | 2020-07-07 | R1 | 0.90 | biosample.attribute:collection_date | 2020-07-07 |
| SAMN28887788 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA: Chicago, IL |
| SAMN28887788 | health_condition | transplant_or_immunocompromised | R1 | 0.70 | sample.name_rule:alias | HTR0001 |
| SAMN28887788 | health_condition_detail | HTR: Project title/description identify these subjects as 'Heart Transplant Patients' / 'HT recipients'; abstract: 'we analyz | R1 | 0.70 | sample.name_rule:alias | HTR0001 |
| SAMN28887788 | latitude | 41.8800 | R1 | 0.90 | biosample.attribute:lat_lon | 41.88 N 87.63 W |
| SAMN28887788 | location_locality | Chicago | R1 | 0.85 | biosample.attribute:geo_loc_name | USA: Chicago, IL |
| SAMN28887788 | location_region | Illinois | R1 | 0.75 | biosample.attribute:geo_loc_name | USA: Chicago, IL |
| SAMN28887788 | longitude | -87.6300 | R1 | 0.90 | biosample.attribute:lat_lon | 41.88 N 87.63 W |
| SAMN28887788 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
Sequencing
48 runs over 48 samples · mean 2.18 Gbp per run (median 1.91 Gbp, total 104.65 Gbp; 48 runs with a base count) · layout PAIRED 48 · platform ILLUMINA 48 · models NextSeq 500 (43), Illumina NovaSeq 6000 (5) · 96% of runs with a Sandpiper profile · first public 2022-06-21
Authors (45)
Dela Cruz M first · Lin H · Han J · Adler E · Boissiere J · Khalid M · Sidebottom A · Sundararajan A · Lehmann C · Moran A · Odenwald M · Stutz M · Kim G · Pinney S · Jeevanandam V · Alegre ML · Pamer E · Nguyen AB last · Mullowney MW first · Hernandez A · McMillin M · Rose AR · Moran D · Little J · Patel BK · Lehmann CJ · Odenwald MA · Pamer EG · Yeo KJ · Sidebottom AM last · Green ER first · Negretti NM · Brunner TH · Shealy NG · Moser FA · Drury SL · Traina KA · Reyes Ruiz VM · Yang TS · Byndloss MX · van de Plas R · Zackular JP · Light SH · Sucre JMS · Skaar EP last
Downloads
PRJNA845905.csv.gz (2.8 KB) · parquet (73.7 KB) — all 48 samples, every field with route and confidence · PRJNA845905_determinations.csv.gz (5.5 KB) — 528 evidence rows