Phase I ibezapolstat vs vancomycin gut microbiome study, USA
240 stool samples from healthy adult volunteers in the USA in a Phase I intervention study comparing ibezapolstat (two doses) and vancomycin, assessing microbiome and bile acid changes relevant to C. difficile infection recurrence risk. machine-written summary
240 samples · 240 runs · US · Adult · 2022 · 80.4 Mbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 720 sample values (collection date, country, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 480 sample values (health condition, health condition detail) · PMC9380534 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Antibiotic given as the study intervention (incl. eradication therapy design randomized_controlled_trial · population healthy_control · Ibezapolstat vs vancomycin vs placebo, Phase I healthy volunteers
“given either ibezapolstat or vancomycin” — abstract:35862742 (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “stool collected daily from Day 0 (baseline) through Day 13, plus a Day 30 follow-up if available” (time origin: intervention start); stated follow-up 30 d.
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 240 | 100% | ||||
| country | 240 | 100% | 240 | |||
| health_condition | 240 | 100% | 240 | |||
| subject_id | 240 | 100% | 240 | |||
| collection_date | 240 | 100% | 240 | |||
| health_condition_detail | 240 | 100% | 240 |
- Functional and Metagenomic Evaluation of Ibezapolstat for Early Evaluation of Anti-Recurrence Effects in Clostridioides difficile Infection. 2022 PMID 35862742 PMC9380534 own_data
Archive description
Microbiome results from the phase I ibezapolstat studies
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN28920112 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMN28920112 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN28920112 | health_condition | healthy_control | R3 | 0.70 | paper.fulltext.methods | healthy volunteer study |
| SAMN28920112 | health_condition_detail | healthy volunteer study, ibezapolstat/vancomycin/placebo arms | R3 | 0.70 | paper.fulltext.methods | healthy volunteer study |
| SAMN28920112 | subject_id | AX-011 | R1 | 0.85 | sample.attr.unique_identifier | AX-011 |
Sequencing
240 runs over 240 samples · mean 96.5 Mbp per run (median 80.4 Mbp, total 23.15 Gbp; 240 runs with a base count) · layout PAIRED 240 · platform ILLUMINA 240 · models NextSeq 500 (240) · 0% of runs with a Sandpiper profile · first public 2022-06-30 – 2022-08-11
Authors (10)
McPherson J first · Hu C · Begum K · Wang W · Lancaster C · Gonzales-Luna AJ · Loveall C · Silverman MH · Alam MJ · Garey KW last
Downloads
PRJNA847068.csv.gz (6.4 KB) · parquet (79.0 KB) — all 240 samples, every field with route and confidence · PRJNA847068_determinations.csv.gz (7.5 KB) — 1,200 evidence rows