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PRJNA850128 SRP382216

Microbiota in sepsis-induced cardiomyopathy, cross-sectional

Gut microbiota dysbiosis is associated with sepsis-induced cardiomyopathy in patients

Cross-sectional study of 31 fecal samples from patients with sepsis-induced cardiomyopathy (16 elderly, 15 adult), examining gut microbial community dysbiosis associated with the condition. machine-written summary

31 samples · 31 runs · Adult · 2023 · 12.17 Gbp / sample

Sources
✓Sequence archive 62✓Abstract / description 93–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive62 sample values (age, sex)
✓ Abstract / description93 sample values (health condition, health condition detail, subject id)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
Age
elderly16
adult15
Condition
other_disease31
Sex
male20
female11
Body site
primary31
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 7 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 24 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 12.17 Gbp per sample0130Gbp
Community composition
Bacteroides 11.2%Klebsiella 10.2%Escherichia 5.5%Alistipes 5.1%Phocaeicola 4.8%Sediminibacterium 4.2%Parabacteroides 4.2%Enterococcus_B 3.8%Megamonas 3.7%Bifidobacterium 2.4%Enterocloster 2.1%Enterococcus_A 2.0%not assigned to a genus 5.4%other genera 35.5%

Genera, mean relative abundance over 28 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category31 100%
country0 0%
health_condition31 100%31
subject_id31 100%31
age_at_collection_days31 100%31
health_condition_detail31 100%31
sex31 100%31
Papers (1)
  • Gut microbiota dysbiosis is associated with sepsis-induced cardiomyopathy in patients: A case-control study. 2023 PMID 36319439 own_data
Details
Archive description

Analysis of gut microbial community in feces of patients with septic myocardium

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult and elderly by sonnet_x2 with confidence 0.57. Assay shotgun_dna.

  • host run.scientific_name · “Homo sapiens”
  • body site study.description · “feces of patients with septic myocardium”
  • life stage study.title · “patients”
  • life stage sample.attr.age · “82 (n=18/31)”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN29157877age_at_collection_days26298.0R10.70sample.attr.age72
SAMN29157877health_conditionother_diseaseR40.50study.titlesepsis-induced cardiomyopathy in patients
SAMN29157877health_condition_detailSepsis-induced cardiomyopathyR40.50study.titlesepsis-induced cardiomyopathy in patients
SAMN29157877sexfemaleR10.90sample.attr.sexfemale
SAMN29157877subject_idSAMN29157877R40.60design.one_sample_per_subject:abstractSICM patients (n = 15) and sepsis-uninduced cardiomyopathy patients (SNICM, n = 16)
Sequencing

31 runs over 31 samples · mean 13.22 Gbp per run (median 12.17 Gbp, total 409.82 Gbp; 31 runs with a base count) · layout PAIRED 31 · platform ILLUMINA 31 · models Illumina NovaSeq 6000 (31) · 90% of runs with a Sandpiper profile · first public 2023-10-29

Authors (0)

No author record.

Downloads

PRJNA850128.csv.gz (1.9 KB) · parquet (70.8 KB) — all 31 samples, every field with route and confidence · PRJNA850128_determinations.csv.gz (1.7 KB) — 155 evidence rows

Samples (31 · every field this project has values for · hover a cell for its source)
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