SCD vs Mediterranean diet RCT in adults with Crohn's disease

This study compared the effectiveness of the Specific Carbohydrate Diet (SCD) to the Mediterranean diet (MD) as treatment for Crohn's disease (CD) with mild to moderate symptoms. Adult patients with CD and with mild-to-moderate symptoms were randomly assigned 1:1 to consume the MD or SCD for 12 weeks. For the first 6 weeks, participants received prepared meals and snacks according to their assigned diet. After 6 weeks, participants were instructed to follow the diet independently. The primary outcome was symptomatic remission at week 6. Key secondary outcomes at week 6 included fecal calprotectin (FC) response (FC <250 g/g and reduction by >50% among those with baseline FC >250 g/g) and C-reactive protein (CRP) response (high-sensitivity CRP <5 mg/L and >50% reduction from baseline among those with high-sensitivity CRP >5 mg/L). The study randomized 194 patients, and 191 were included in the efficacy analyses. The percentage of participants who achieved symptomatic remission at week 6 was not superior with the SCD (SCD, 46.5% MD, 43.5% P = .77). FC response was achieved in 8 of 23 participants (34.8%) with the SCD and in 4 of 13 participants (30.8%) with the MD (P = .83). CRP response was achieved in 2 of 37 participants (5.4%) with the SCD and in 1 of 28 participants (3.6%) with the MD (P = .68). The SCD was not superior to the MD to achieve symptomatic remission, FC response, and CRP response. CRP response was uncommon. Given these results, the greater ease of following the MD and other health benefits associated with the MD, the MD may be preferred to the SCD for most patients with CD with mild to moderate symptoms. ClinicalTrials.gov Identifier: NCT03058679

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

• host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
• body site study.description · “week 6 included fecal calprotectin (FC) response”
• body site external_curation.infant_catalog · “body_site_call gut”
• life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
• life stage study.title · “Mediterranean Diet in Adults With Crohn's Disease”

339 runs over 339 samples · mean 1.84 Gbp per run (median 1.92 Gbp, total 622.81 Gbp; 339 runs with a base count) · layout PAIRED 339 · platform ILLUMINA 339 · models Illumina HiSeq 2500 (339) · 82% of runs with a Sandpiper profile · first public 2024-06-30

No author record.

PRJNA854889.csv.gz (10.7 KB) · parquet (85.2 KB) — all 339 samples, every field with route and confidence · PRJNA854889_determinations.csv.gz (29.6 KB) — 4,407 evidence rows