FMT for IBS in adults, Hong Kong (RCT)
275 gut metagenome samples from adults with irritable bowel syndrome in Hong Kong, studying fecal microbiota transplantation via OGD in a randomized, double-blind, placebo-controlled trial. machine-written summary
275 samples · 275 runs · HK · Adult · 2024 · 8.59 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 1,100 sample values (collection date, country, latitude, longitude) |
| ✓ Abstract / description | 550 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation design randomized_controlled_trial · population ibs · Twice FMT via OGD, 4-week interval, placebo-controlled, IBS
“Faecal Microbiota Transplantation in patients with irritable bowel syndrome” — study.title (study level; per-sample arms are in the intervention column below)
longitudinal — not resolved
Schedule stated by the source: “FMT given at baseline and week 4; outcomes assessed at week 12; open-label FMT offered after 12-week follow-up” (time origin: intervention_start); stated follow-up 3 mo.
Genera, mean relative abundance over 232 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 275 | 100% | ||||
| country | 275 | 100% | 275 | |||
| health_condition | 275 | 100% | 275 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 275 | 100% | 275 | |||
| health_condition_detail | 275 | 100% | 275 | |||
| latitude | 275 | 100% | 275 | |||
| longitude | 275 | 100% | 275 |
- Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea. 2023 PMID 37667968 own_data
Archive description
In this RCT, we aim to evaluate the efficacy of twice FMT at an interval of four weeks via oesophago-gastro-duodenoscopy (OGD) in alleviating IBS.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Faecal Microbiota Transplantation in”
- body site study.description · “weeks via oesophago-gastro- duodenoscopy (OGD) in alleviating”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN43215228 | collection_date | 2022-06 | R1 | 0.90 | biosample.attribute:collection_date | 2022-06 |
| SAMN43215228 | country | HK | R1 | 0.90 | sample.attr.geo_loc_name | Hong Kong |
| SAMN43215228 | health_condition | ibs | R4 | 0.50 | paper.abstract | 56 patients with diarrhoea-predominant IBS 1:1 to FMT or placebo via the duodenal route |
| SAMN43215228 | health_condition_detail | diarrhoea-predominant IBS | R4 | 0.50 | paper.abstract | 56 patients with diarrhoea-predominant IBS 1:1 to FMT or placebo via the duodenal route |
| SAMN43215228 | latitude | 22.3000 | R1 | 0.90 | biosample.attribute:lat_lon | 22.30 N 114.17 E |
| SAMN43215228 | longitude | 114.1700 | R1 | 0.90 | biosample.attribute:lat_lon | 22.30 N 114.17 E |
Sequencing
275 runs over 275 samples · mean 10.46 Gbp per run (median 8.59 Gbp, total 2,875.68 Gbp; 275 runs with a base count) · layout PAIRED 275 · platform ILLUMINA 275 · models Illumina NovaSeq 6000 (275) · 84% of runs with a Sandpiper profile · first public 2024-08-22
Authors (0)
No author record.
Downloads
PRJNA871036.csv.gz (7.2 KB) · parquet (79.5 KB) — all 275 samples, every field with route and confidence · PRJNA871036_determinations.csv.gz (8.1 KB) — 1,650 evidence rows