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PRJNA888860 SRP402199

Gut microbiome, metabolome in colon cancer, Shanghai

Comprehensive multi-omics analysis of microbiome, metabolome, and host genome in right- and left-sided colon cancer

230 samples from Shanghai, China, comparing colorectal cancer (142) and healthy controls (88), analyzing microbiome, metabolome and host genomics to distinguish right- and left-sided colon cancer. machine-written summary

230 samples · 230 runs · CN · Age unknown · 2024 · 10.47 Gbp / sample

Sources
✓Sequence archive 1,610○Abstract / description✓Full text 230–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive1,610 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude)
○ Abstract / descriptionread; no usable statement
✓ Full text230 sample values (subject id)
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
unknown230
Condition
colorectal_cancer142
healthy_control88
Country
CN230
Body site
primary230
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 62 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 168 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 10.47 Gbp per sample0130Gbp
Community composition
Bacteroides 13.0%Phocaeicola 12.7%Prevotella 8.2%Faecalibacterium 7.7%Alistipes 4.7%Roseburia 3.3%Escherichia 2.5%Lachnospira 2.0%Gemmiger 1.9%Ruminococcoides 1.7%Parabacteroides 1.5%Vescimonas 1.4%not assigned to a genus 4.1%other genera 35.4%

Genera, mean relative abundance over 210 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country230 100%230
health_condition230 100%230
subject_id230 100%230
collection_date230 100%230
detailed_location230 100%
health_condition_detail230 100%230
latitude230 100%230
location_region230 100%230
longitude230 100%230
Details
Archive description

The distinct bacteria, metabolites and host genomics bring us a new dimension to define RCC and LCC

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.75. Assay shotgun_dna.

  • host run.host_tax_id · “9606”
  • body site run.scientific_name · “human metagenome”
  • body site study.title · “right- and left-sided colon cancer”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN31901444collection_date2018R10.90biosample.attribute:collection_date2018
SAMN31901444countryCNR10.90sample.attr.geo_loc_nameChina:Shanghai
SAMN31901444health_conditioncolorectal_cancerR10.70sample.name_rule:sample_aliasCRC_1
SAMN31901444health_condition_detailCRCR10.70sample.name_rule:sample_aliasCRC_1
SAMN31901444latitude31.0000R10.90biosample.attribute:lat_lon31 N 121 E
SAMN31901444location_regionShanghaiR10.85biosample.attribute:geo_loc_nameChina:Shanghai
SAMN31901444longitude121.0000R10.90biosample.attribute:lat_lon31 N 121 E
SAMN31901444subject_idSAMN31901444R30.70design.one_sample_per_subject:fulltextfecal samples from 230 preoperative patients with CRC and healthy controls were collected and detected by metagenomic sequencing
Sequencing

230 runs over 230 samples · mean 10.85 Gbp per run (median 10.47 Gbp, total 2,496.65 Gbp; 230 runs with a base count) · layout PAIRED 230 · platform ILLUMINA 230 · models Illumina NovaSeq 6000 (230) · 91% of runs with a Sandpiper profile · first public 2024-01-01

Authors (0)

No author record.

Downloads

PRJNA888860.csv.gz (6.6 KB) · parquet (79.6 KB) — all 230 samples, every field with route and confidence · PRJNA888860_determinations.csv.gz (12.0 KB) — 1,840 evidence rows

Samples (230 · every field this project has values for · hover a cell for its source)
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