Home › Studies › PRJNA896226
PRJNA896226 SRP405725

Fecal microbiome in pancreatic cancer survivors, Ohio, USA

Analysis of the Fecal Metagenome in Long Term Survivors of Pancreas Cancer

Cross-sectional study of 24 fecal samples from adults in Ohio, USA, comparing 16 samples from other-cancer patients and 8 healthy controls to examine microbiome features linked to long-term pancreatic cancer survival. machine-written summary

24 samples · 24 runs · US · Adult · 2023 · 1.35 Gbp / sample

Sources
✓Sequence archive 120✓Abstract / description 24–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive120 sample values (collection date, country, health condition, health condition detail, location region)
✓ Abstract / description24 sample values (subject id)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 country
Age
adult24
Condition
other_cancer16
healthy_control8
Country
US24
Body site
primary24
Collected 2020–2021
2020: 17 samples2021: 7 samples20202021
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 2 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)this project, 1–3 Gbp: 16 samplesall projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 6 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 1.35 Gbp per sample0130Gbp
Community composition
Bacteroides 10.7%Blautia_A 6.1%Prevotella 6.1%Roseburia 5.6%Phocaeicola 5.6%Streptococcus 4.5%Alistipes 3.6%Faecalibacterium 3.1%Klebsiella 2.0%Ruminococcoides 1.9%Akkermansia 1.6%Parabacteroides 1.6%not assigned to a genus 9.1%other genera 38.5%

Genera, mean relative abundance over 21 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category24 100%
country24 100%24
health_condition24 100%24
subject_id24 100%24
collection_date24 100%24
detailed_location24 100%
health_condition_detail24 100%24
location_region24 100%24
Papers (1)
  • Analysis of the fecal metagenome in long-term survivors of pancreas cancer. 2023 PMID 36943918 own_data
Details
Archive description

Analysis of pancreatic cancer survivors to identify microbiome features associated with long term survival .

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.

  • host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
  • body site study.title · “Analysis of the Fecal Metagenome in Long”
  • body site external_curation.infant_catalog · “body_site_call gut”
  • life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN31537919collection_date2021-05-05R10.90biosample.attribute:collection_date2021-05-05
SAMN31537919countryUSR10.90sample.attr.geo_loc_nameUSA: Ohio
SAMN31537919health_conditionother_cancerR10.85biosample.attribute:DESCRIPTIONDESCRIPTION: LTS
SAMN31537919health_condition_detailLTSR10.85biosample.attribute:DESCRIPTIONDESCRIPTION: LTS
SAMN31537919location_regionOhioR10.85biosample.attribute:geo_loc_nameUSA: Ohio
SAMN31537919subject_idSAMN31537919R40.65design.one_sample_per_subject:abstractIn this cross-sectional study, comprehensive shotgun metagenomics was performed on stool from PCa patients
Sequencing

24 runs over 24 samples · mean 1.94 Gbp per run (median 1.35 Gbp, total 46.53 Gbp; 24 runs with a base count) · layout PAIRED 24 · platform ILLUMINA 24 · models Illumina NovaSeq 6000 (24) · 88% of runs with a Sandpiper profile · first public 2023-11-02

Authors (0)

No author record.

Downloads

PRJNA896226.csv.gz (1.6 KB) · parquet (70.5 KB) — all 24 samples, every field with route and confidence · PRJNA896226_determinations.csv.gz (1.8 KB) — 144 evidence rows

Samples (24 · every field this project has values for · hover a cell for its source)
Loading the sample table…