Gut microbiome and sex-specific aging in Hainan centenarians
Cross-sectional study of 75 gut metagenome samples from elderly and infant residents of Hainan, China (Lingao, Danzhou, Chengmai), all healthy controls, examining the gut microbiome as a sex-specific modulator of healthy aging. machine-written summary
75 samples · 75 runs · CN · Adult · 2023 · 11.68 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 587 sample values (age, collection date, country, latitude, location locality, location region, longitude, sex) |
| ✓ Abstract / description | 150 sample values (health condition, health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
age: two sequence archives disagree for 12 samples (e.g. 102.0 vs 37255.5) — withheld.
The sources disagree on 12 samples. Where two incompatible values exist for one sample (or one person's samples disagree on sex), neither value is published: the field is left empty here, in the sample sheet and in the downloads. Both sides, with their sources, are in gut_metadata_contradictions.parquet of the data package (what counts as a contradiction).
Contradicted values (12)
| sample | field | value | other value | handling |
|---|---|---|---|---|
| SAMN31842721 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842731 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842744 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842746 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842752 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842758 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842760 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842769 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842770 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842772 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842784 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
| SAMN31842790 | age | 102.0 (sequence archive) | 37255.5 (sequence archive) | withheld: neither value published |
Genera, mean relative abundance over 69 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 75 | 100% | ||||
| country | 75 | 100% | 75 | |||
| health_condition | 75 | 100% | 75 | |||
| subject_id | 0 | 0% | ||||
| collection_date | 75 | 100% | 75 | |||
| detailed_location | 75 | 100% | ||||
| health_condition_detail | 75 | 100% | 75 | |||
| latitude | 75 | 100% | 75 | |||
| location_locality | 75 | 100% | 75 | |||
| location_region | 75 | 100% | 75 | |||
| longitude | 75 | 100% | 75 | |||
| sex | 75 | 100% | 75 | |||
| age_at_collection_days | 62 | 83% | 62 |
- A metagenomics study reveals the gut microbiome as a sex-specific modulator of healthy aging in Hainan centenarians. 2024 PMID 38185288 own_data
Archive description
the sex-specific gut microbiome to extreme longevity
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “study reveals the gut microbiome as a”
- body site study.description · “the sex-specific gut microbiome to extreme”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “aging in Hainan centenarians”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN31842719 | age_at_collection_days | 36890.2 | R1 | 0.70 | sample.attr.host_age | 101 |
| SAMN31842719 | collection_date | 2016-10-26 | R1 | 0.90 | biosample.attribute:collection_date | 2016-10-26 |
| SAMN31842719 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Hainan,Danzhou |
| SAMN31842719 | health_condition | healthy_control | R4 | 0.50 | paper.abstract | gut microbiome in healthy centenarians and to explore |
| SAMN31842719 | health_condition_detail | healthy centenarians | R4 | 0.50 | paper.abstract | gut microbiome in healthy centenarians and to explore |
| SAMN31842719 | latitude | 19.5100 | R1 | 0.90 | biosample.attribute:lat_lon | 19.51 N 109.57 E |
| SAMN31842719 | location_locality | Danzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Hainan,Danzhou |
| SAMN31842719 | location_region | Hainan | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Hainan,Danzhou |
| SAMN31842719 | longitude | 109.5700 | R1 | 0.90 | biosample.attribute:lat_lon | 19.51 N 109.57 E |
| SAMN31842719 | sex | female | R1 | 0.90 | sample.attr.host_sex | female |
Sequencing
75 runs over 75 samples · mean 13.02 Gbp per run (median 11.68 Gbp, total 976.70 Gbp; 75 runs with a base count) · layout PAIRED 75 · platform ILLUMINA 75 · models Illumina HiSeq 4000 (75) · 92% of runs with a Sandpiper profile · first public 2023-03-24
Authors (0)
No author record.
Downloads
PRJNA904419.csv.gz (3.1 KB) · parquet (74.1 KB) — all 75 samples, every field with route and confidence · PRJNA904419_determinations.csv.gz (5.9 KB) — 737 evidence rows