Gut metagenomics in essential tremor, Guangzhou case-control
10 fecal samples from adults in Guangzhou, China, comparing gut microbiota GABA-producing capacity between essential tremor patients and healthy controls, in a case-control design involving FMT and probiotic (L. plantarum L5) interventions. machine-written summary
10 samples · 10 runs · CN · Adult · 2023 · 11.05 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 70 sample values (collection date, country, health condition, health condition detail, latitude, location locality, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 20 sample values (location site, subject id) · PMC10717605 |
| ✓ Supplementary tables | 10 sample values (age, sex) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Faecal microbiota transplantation Probiotic (live microorganisms; single strain or mixture) design single_arm_before_after · population neurological_psychiatric · FMT from ET patients to mice; L. plantarum L5 probiotic treatment in mice
“mice were treated with the high-GABA-producing strain Lactobacillus plantarum L5” — abstract:38093327 (study level; per-sample arms are in the intervention column below)
Genera, mean relative abundance over 10 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 10 | 100% | ||||
| country | 10 | 100% | 10 | |||
| health_condition | 10 | 100% | 10 | |||
| subject_id | 10 | 100% | 10 | |||
| collection_date | 10 | 100% | 10 | |||
| detailed_location | 10 | 100% | ||||
| health_condition_detail | 10 | 100% | 10 | |||
| latitude | 10 | 100% | 10 | |||
| location_locality | 10 | 100% | 10 | |||
| location_site | 10 | 100% | 10 | |||
| longitude | 10 | 100% | 10 | |||
| age_at_collection_days | 5 | 50% | 5 | |||
| sex | 5 | 50% | 5 |
- Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA. 2023 PMID 38093327 PMC10717605 own_data
Archive description
This study aimed to investigate whether the GABA-producing property of gut microbiota was associated with or even contributed to essential tremor.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “by reduction of gut bacterial-derived GABA is”
- body site study.description · “GABA-producing property of gut microbiota was associated”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN31847021 | age_at_collection_days | 20089.0 | R2 | 0.80 | paper.supp.40035_2023_391_MOESM1_ESM.docx[table2!Age (years)] | 55 |
| SAMN31847020 | collection_date | 2020-09-17 | R1 | 0.90 | biosample.attribute:collection_date | 2020-09-17 |
| SAMN31847020 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China: Guangzhou |
| SAMN31847020 | health_condition | neurological_psychiatric | R1 | 0.85 | biosample.attribute:DESCRIPTION | DESCRIPTION: patient with essential tremor |
| SAMN31847020 | health_condition_detail | patient with essential tremor | R1 | 0.85 | biosample.attribute:DESCRIPTION | DESCRIPTION: patient with essential tremor |
| SAMN31847020 | latitude | 23.1300 | R1 | 0.90 | biosample.attribute:lat_lon | 23.13 N 113.30 E |
| SAMN31847020 | location_locality | Guangzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China: Guangzhou |
| SAMN31847020 | location_site | First Affiliated Hospital of Guangdong Pharmaceutical University | R3 | 0.70 | paper.fulltext.methods | First Affiliated Hospital of Guangdong Pharmaceutical University (Guangzhou, China) |
| SAMN31847020 | longitude | 113.3000 | R1 | 0.90 | biosample.attribute:lat_lon | 23.13 N 113.30 E |
| SAMN31847021 | sex | male | R2 | 0.80 | paper.supp.40035_2023_391_MOESM1_ESM.docx[table2!Sex] | Male |
| SAMN31847020 | subject_id | SAMN31847020 | R3 | 0.70 | design.one_sample_per_subject:fulltext | Fresh fecal samples, 100 g each from healthy controls ( n = 5) or patients with ET ( n = 5) |
Sequencing
10 runs over 10 samples · mean 11.24 Gbp per run (median 11.05 Gbp, total 112.44 Gbp; 10 runs with a base count) · layout PAIRED 10 · platform ILLUMINA 10 · models Illumina NovaSeq 6000 (10) · 100% of runs with a Sandpiper profile · first public 2023-06-05
Authors (13)
Zhong HJ first · Wang SQ · Zhang RX · Zhuang YP · Li L · Yi SZ · Li Y · Wu L · Ding Y · Zhang J · Xie X · He XX · Wu Q last
Downloads
PRJNA904560.csv.gz (1.4 KB) · parquet (71.8 KB) — all 10 samples, every field with route and confidence · PRJNA904560_determinations.csv.gz (1.8 KB) — 100 evidence rows