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PRJNA909793 SRP411865

Gut microbiome in colorectal cancer survivors, US

Lifestyle and Outcomes after Gastrointestinal Cancer (LOGIC) - microbiome study

Cross-sectional pilot study of 28 stool samples from colorectal cancer survivors at the University of California, San Francisco (2019–2020), examining associations between ACS lifestyle guideline adherence (diet, activity, alcohol) and gut microbiome composition. machine-written summary

28 samples · 28 runs · US · Adult · 2022 · 8.50 Gbp / sample

Sources
✓Sequence archive 224✓Abstract / description 28✓Full text 28○Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive224 sample values (collection date, country, health condition, health condition detail, latitude, location region, longitude, subject id)
✓ Abstract / description28 sample values (location site)
✓ Full text28 sample values (location locality) · PMC10550847
○ Supplementary tablesfiles read; no table could be matched to the samples
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
adult28
Condition
colorectal_cancer28
Country
US28
Body site
primary28
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)all projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 23 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)this project, 10–30 Gbp: 5 samplesall projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 8.50 Gbp per sample0130Gbp
Community composition
Bacteroides 9.8%Faecalibacterium 6.1%Roseburia 5.0%Alistipes 4.8%Blautia_A 3.8%Phocaeicola 3.6%Bifidobacterium 3.5%Ruminococcoides 2.8%Escherichia 2.4%Gemmiger 2.1%Streptococcus 1.7%Akkermansia 1.5%not assigned to a genus 4.4%other genera 48.5%

Genera, mean relative abundance over 26 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category28 100%
country28 100%28
health_condition28 100%28
subject_id28 100%28
collection_date28 100%28
detailed_location28 100%
health_condition_detail28 100%28
latitude28 100%28
location_locality28 100%28
location_region28 100%28
location_site28 100%28
longitude28 100%28
Papers (1)
  • Variety of Fruit and Vegetables and Alcohol Intake are Associated with Gut Microbial Species and Gene Abundance in Colorectal Cancer Survivors. 2023 PMID 37474105 PMC10550847 own_data
Details
Archive description

The goal of the LOGIC study is to examine associations between health behaviors and variations in the gut microbiome among gastrointestinal cancer survivors.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of adult by sonnet_x2 with confidence 0.60. Assay shotgun_dna.

  • host run.host_tax_id · “9606”
  • body site study.title · “microbiome study”
  • life stage study.title · “Gastrointestinal Cancer”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN32096118collection_date2019R10.90biosample.attribute:collection_date2019
SAMN32096118countryUSR10.90sample.attr.geo_loc_nameUSA
SAMN32096118health_conditioncolorectal_cancerR10.85biosample.attribute:gastrointest_disordColorectal cancer
SAMN32096118health_condition_detailColorectal cancerR10.90sample.attr.gastrointest_disordColorectal cancer
SAMN32096118latitude36.7783R10.90biosample.attribute:lat_lon36.7783 N 119.4179 W
SAMN32096118location_localitySan FranciscoR30.70paper.fulltext.abstractUniversity of California, San Francisco from 2019 to 2020
SAMN32096118location_regionCaliforniaR10.60biosample.attribute:lat_lon36.7783 N 119.4179 W
SAMN32096118location_siteUniversity of California, San FranciscoR40.45paper.abstractcollected from 28 CRC survivors at the University of California, San Francisco
SAMN32096118longitude-119.4179R10.90biosample.attribute:lat_lon36.7783 N 119.4179 W
SAMN32096118subject_idLOGICS-8350003R10.85sample.attr.host_subject_idLOGICS-8350003
Sequencing

28 runs over 28 samples · mean 8.59 Gbp per run (median 8.50 Gbp, total 240.60 Gbp; 28 runs with a base count) · layout PAIRED 28 · platform ILLUMINA 28 · models Illumina NovaSeq 6000 (28) · 93% of runs with a Sandpiper profile · first public 2022-12-10

Authors (16)

Kyaw TS first · Upadhyay V · Tolstykh I · Van Loon K · Laffan A · Stanfield D · Gempis D · Kenfield SA · Chan JM · Piawah S · Atreya CE · Ng K · Venook A · Kidder W · Turnbaugh PJ · Van Blarigan EL last

Downloads

PRJNA909793.csv.gz (1.8 KB) · parquet (71.8 KB) — all 28 samples, every field with route and confidence · PRJNA909793_determinations.csv.gz (2.5 KB) — 280 evidence rows

Samples (28 · every field this project has values for · hover a cell for its source)
Loading the sample table…