Gut microbiota in Chinese children with NAFLD, Beijing
Case-control study of 62 fecal samples from children in Beijing, China, comparing gut microbiota between those with nonalcoholic fatty liver disease (NAFLD/NAFL/NASH) and healthy controls using 16S rRNA and metagenomic sequencing. machine-written summary
62 samples · 62 runs · CN · Child · 2023 · 8.29 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 186 sample values (collection date, country, location locality) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 124 sample values (antibiotic exposure, location site) · PMC10846053, PMC12101585 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 54 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 62 | 100% | ||||
| country | 62 | 100% | 62 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| antibiotic_exposure | 62 | 100% | 62 | |||
| collection_date | 62 | 100% | 62 | |||
| detailed_location | 62 | 100% | ||||
| location_locality | 62 | 100% | 62 | |||
| location_site | 62 | 100% | 62 |
- Role of intestinal flora in the development of nonalcoholic fatty liver disease in children. 2024 PMID 38189294 PMC10846053 own_data
- Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH. 2025 PMID 40396204 PMC12101585 unsure
Archive description
normal Illumina of gut microbiota of NAFLD Children
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of child by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- body site study.title · “gut microbiota of Children”
- body site study.description · “normal Illumina of gut microbiota of NAFLD”
- life stage external_curation.infant_catalog · “infant triage reason_code age_child_over_36m”
- life stage study.title · “gut microbiota of Children NAFLD Raw sequence”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN32338763 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | antibiotic intake within 2 months |
| SAMN32338763 | collection_date | 2019-12-11 | R1 | 0.90 | biosample.attribute:collection_date | 2019-12-11 |
| SAMN32338763 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Beijing |
| SAMN32338763 | location_locality | Beijing | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Beijing |
| SAMN32338763 | location_site | Beijing Children's Hospital | R3 | 0.70 | paper.fulltext.methods | Pathological Department, Beijing Children's Hospital |
Sequencing
62 runs over 62 samples · mean 7.33 Gbp per run (median 8.29 Gbp, total 454.26 Gbp; 62 runs with a base count) · layout SINGLE 62 · platform ILLUMINA 62 · models Illumina NovaSeq 6000 (62) · 87% of runs with a Sandpiper profile · first public 2023-01-31 – 2023-02-01
Authors (27)
Zhang J first · Shi M · Zhao C · Liang G · Li C · Ge X · Pei C · Kong Y · Li D · Yang W · Cao B · Fu L · Yan Y · Wu J · Zhou J · Fang Y · Meng X · Li Y · Wang L · Zöggeler T first · Kavallar AM · Pollio AR · Aldrian D · Decristoforo C · Scholl-Bürgi S · Müller T · Vogel GF last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA914785.csv.gz (2.5 KB) · parquet (71.8 KB) — all 62 samples, every field with route and confidence · PRJNA914785_determinations.csv.gz (2.6 KB) — 310 evidence rows