Sulfasalazine & gut microbiome in IBD-associated pSpA, US
38 gut microbiome samples from adult and elderly IBD-associated peripheral spondyloarthritis patients in the USA, studying sulfasalazine drug therapy in an intervention design. machine-written summary
38 samples · 38 runs · US · Adult · 2023 · 0.42 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 417 sample values (age, collection date, country, health condition, health condition detail, latitude, location region, longitude) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 38 sample values (antibiotic exposure) · PMC10982976 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
intervention — arms not resolved
Non-antibiotic pharmaceutical given as the study intervention (metformin design single_arm_before_after · population autoimmune_inflammatory · Sulfasalazine therapy in IBD-associated pSpA subjects
“treatment of 22 IBD-pSpA subjects with sulfasalazine” — abstract:38378002 (study level; per-sample arms are in the intervention column below)
longitudinal
19 of 19 people sampled more than once (38 samples; median 2, up to 2 per person) · follow-up median 3 mo (max 5 mo) · median interval between samples 3 mo (time from collection dates). Schedule stated by the source: “Baseline and week 12 fecal sampling for each subject during sulfasalazine treatment”; stated follow-up 3 mo.
Each row is one person (19 shown); dots are samples at days since that person's first sample.
Genera, mean relative abundance over 37 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 38 | 100% | ||||
| country | 38 | 100% | 38 | |||
| health_condition | 38 | 100% | 38 | |||
| subject_id | 38 | 100% | 38 | |||
| age_at_collection_days | 38 | 100% | 38 | |||
| antibiotic_exposure | 38 | 100% | 38 | |||
| collection_date | 38 | 100% | 38 | |||
| detailed_location | 38 | 100% | ||||
| health_condition_detail | 38 | 100% | 38 | |||
| latitude | 38 | 100% | 38 | |||
| location_region | 38 | 100% | 38 | |||
| longitude | 38 | 100% | 38 | |||
| sex | 38 | 100% | 38 | |||
| timepoint_label | 37 | 97% | 37 |
- The gut microbiome regulates the clinical efficacy of sulfasalazine therapy for IBD-associated spondyloarthritis. 2024 PMID 38378002 PMC10982976 own_data
Archive description
Role of sulfasalazine therapy in regulating the gut microbiome and joint symptoms in IBD-associated pSpA
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “in regulating the gut microbiome and joint”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage sample.attr.host_age · “76 (n=8/38)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN32964121 | age_at_collection_days | 9496.5 | R1 | 0.85 | sample.attr.host_age | 26 |
| SAMN32964121 | antibiotic_exposure | no | R3 | 0.70 | paper.fulltext.methods | antibiotic use within 8 weeks prior enrollment |
| SAMN32964121 | collection_date | 2015-12-22 | R1 | 0.90 | biosample.attribute:collection_date | 2015-12-22 |
| SAMN32964121 | country | US | R1 | 0.90 | sample.attr.geo_loc_name | USA |
| SAMN32964121 | health_condition | autoimmune_inflammatory | R1 | 0.90 | biosample_attr | IBD_peripheral SpA |
| SAMN32964121 | health_condition_detail | UC | R1 | 0.90 | sample.attr.gastrointest_disord | UC |
| SAMN32964121 | latitude | 40.7655 | R1 | 0.90 | biosample.attribute:lat_lon | 40.7655 N 73.9550 W |
| SAMN32964121 | location_region | New York | R1 | 0.60 | biosample.attribute:lat_lon | 40.7655 N 73.9550 W |
| SAMN32964121 | longitude | -73.9550 | R1 | 0.90 | biosample.attribute:lat_lon | 40.7655 N 73.9550 W |
| SAMN32964121 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMN32964121 | subject_id | 2 | R1 | 0.70 | sample.name_rule:alias | 2_0 |
| SAMN32964121 | timepoint_label | baseline | R1 | 0.70 | sample.name_rule:alias | 2_0 |
Sequencing
38 runs over 38 samples · mean 0.43 Gbp per run (median 0.42 Gbp, total 16.28 Gbp; 38 runs with a base count) · layout PAIRED 38 · platform ILLUMINA 38 · models Illumina HiSeq 4000 (38) · 97% of runs with a Sandpiper profile · first public 2023-12-05
Authors (19)
Lima SF first · Pires S · Rupert A · Oguntunmibi S · Jin WB · Marderstein A · Funez-dePagnier G · Maldarelli G · Viladomiu M · Putzel G · Yang W · Tran N · Xiang G · Grier A · Guo CJ · Lukin D · Mandl LA · Scherl EJ · Longman RS last
Downloads
PRJNA929558.csv.gz (2.2 KB) · parquet (72.5 KB) — all 38 samples, every field with route and confidence · PRJNA929558_determinations.csv.gz (4.1 KB) — 455 evidence rows