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PRJNA936589 SRP423365

Gut microbiome in stage III colorectal cancer, Mali

Characterization of the gut microbiota in patients with stage III colorectal cancer: a case-control study

Shotgun metagenome study of 46 gut microbiome samples from Mali, comparing 22 samples from stage III colorectal cancer patients and 24 from healthy controls, using a case-control design. machine-written summary

46 samples · 46 runs · ML · Age unknown · 2023 · 6.84 Gbp / sample

Sources
✓Sequence archive 276✓Abstract / description 46–Full text–Supplementary tables–External resources–User contribution–Human verified

Checked this project's papers and archive records yourself? Mark it human-verified.

what each source gave
✓ Sequence archive276 sample values (collection date, country, health condition, health condition detail, latitude, longitude)
✓ Abstract / description46 sample values (subject id)
– Full textno open-access full text linked
– Supplementary tablesno supplementary tables available (or none open access)
– External resourcesnot covered by the external resources we ingest
– User contributionnothing uploaded yet
– Human verifiednot yet checked by a person · I checked this project — verify it
Samples at a glance
1 sampling locations · 1 country
Age
unknown46
Condition
healthy_control24
colorectal_cancer22
Country
ML46
Body site
primary46
Sequencing depth per sample · this project all projects
all projects, 0–0.03 Gbp: 25,080 samples (4 %)all projects, 0.03–0.1 Gbp: 17,066 samples (3 %)all projects, 0.1–0.3 Gbp: 29,179 samples (5 %)all projects, 0.3–1 Gbp: 47,044 samples (8 %)this project, 0.3–1 Gbp: 1 samplesall projects, 1–3 Gbp: 124,983 samples (22 %)all projects, 3–10 Gbp: 253,728 samples (44 %)this project, 3–10 Gbp: 45 samplesall projects, 10–30 Gbp: 72,533 samples (13 %)all projects, 30–100 Gbp: 3,024 samples (1 %)all projects, 100–300 Gbp: 106 samples (0 %)all projects, ≥ 300 Gbp: 9 samples (0 %)project median 6.84 Gbp per sample0130Gbp
Community composition
Escherichia 8.2%Prevotella 7.6%Bacteroides 6.4%Faecalibacterium 3.8%Akkermansia 3.1%Catenibacterium 2.5%Klebsiella 2.4%CAG-877 2.2%CAG-710 1.6%CAG-302 1.6%Alistipes 1.5%Clostridium 1.5%not assigned to a genus 10.1%other genera 47.6%

Genera, mean relative abundance over 42 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).

Field coverage
fieldsamplescoverageR1R2R3R4
age_category0 0%
country46 100%46
health_condition46 100%46
subject_id46 100%46
collection_date46 100%46
health_condition_detail46 100%46
latitude46 100%46
longitude46 100%46
Papers (1)
  • Characterization of the gut microbiota in patients with stage III colorectal cancer: A case-control study. 2026 PMID 41270896 own_data
Details
Archive description

we used shotgun metagenome sequencing to characterize the gut microbiome in advanced stage of CRC through a case control study in Mali.

How this project entered the registry

Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.72. Assay shotgun_dna.

  • host run.host_tax_id · “9606”
  • body site study.title · “gut microbiota in patients with stage III colorectal cancer”
Evidence examples (one per field × route)
samplefieldvaluerouteconf.sourcequote
SAMN33356256collection_date2018R10.90biosample.attribute:collection_date2018
SAMN33356256countryMLR10.90sample.attr.geo_loc_nameMali
SAMN33356256health_conditioncolorectal_cancerR10.70sample.name_rule:descriptiondescription: CRC
SAMN33356256health_condition_detailCRC (stage III colorectal cancer case)R10.70sample.name_rule:descriptiondescription: CRC
SAMN33356256latitude17.5700R10.90biosample.attribute:lat_lon17.57 N 3.99 W
SAMN33356256longitude-3.9900R10.90biosample.attribute:lat_lon17.57 N 3.99 W
SAMN33356256subject_idSAMN33356256R40.65design.one_sample_per_subject:abstractThis case-control study involved newly diagnosed CRC patients (n = 23) prior to any treatment initiation, and unrelated healthy controls (n = 24)
Sequencing

46 runs over 46 samples · mean 6.69 Gbp per run (median 6.84 Gbp, total 307.78 Gbp; 46 runs with a base count) · layout PAIRED 46 · platform ILLUMINA 46 · models Illumina HiSeq 4000 (46) · 91% of runs with a Sandpiper profile · first public 2023-02-27

Authors (0)

No author record.

Downloads

PRJNA936589.csv.gz (2.1 KB) · parquet (71.4 KB) — all 46 samples, every field with route and confidence · PRJNA936589_determinations.csv.gz (3.0 KB) — 322 evidence rows

Samples (46 · every field this project has values for · hover a cell for its source)
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