Gut metagenomes in major depression vs controls, Wuhan
Case-control metagenomic study of 82 gut samples from adults in Wuhan, China, comparing major depressive disorder patients (40) with healthy controls (42) to identify bacterial and viral biomarkers. machine-written summary
82 samples · 82 runs · CN · Adult · 2024 · 6.72 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 738 sample values (age, bmi, collection date, country, health condition, health condition detail, location locality, sex) |
| ○ Abstract / description | read; no usable statement |
| ○ Full text | read; no usable statement or table · PMC12174422, PMC13470864 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 75 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 82 | 100% | ||||
| country | 82 | 100% | 82 | |||
| health_condition | 82 | 100% | 82 | |||
| subject_id | 82 | 100% | 82 | |||
| age_at_collection_days | 82 | 100% | 82 | |||
| bmi | 82 | 100% | 82 | |||
| collection_date | 82 | 100% | 82 | |||
| detailed_location | 82 | 100% | ||||
| health_condition_detail | 82 | 100% | 82 | |||
| location_locality | 82 | 100% | 82 | |||
| sex | 82 | 100% | 82 |
- Metagenomics reveals unique gut mycobiome biomarkers in major depressive disorder - a non-invasive method. 2025 PMID 40535544 PMC12174422 unsure
- Gut microbial biomarkers for major depressive disorder: a cross-sectional study. 2026 PMID 42598412 PMC13470864 unsure
Archive description
We conducted our study to explore the gut microbiomes of young adults with major depressive disorder compared with healthy controls.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.description · “to explore the gut microbiomes of young”
- body site external_curation.infant_catalog · “body_site_call gut”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.title · “reads in young adults with major depression.”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN33714291 | age_at_collection_days | 8766.0 | R1 | 0.85 | sample.attr.host_age | 24 |
| SAMN33714291 | bmi | 23.67 | R1 | 0.90 | sample.attr.host_body_mass_index | 23.67 |
| SAMN33714291 | collection_date | 2020-11-20 | R1 | 0.90 | biosample.attribute:collection_date | 2020-11-20 |
| SAMN33714291 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:Wuhan |
| SAMN33714291 | health_condition | healthy_control | R1 | 0.90 | biosample_attr | Healthy control |
| SAMN33714291 | health_condition_detail | Healthy control | R1 | 0.90 | sample.attr.host_disease | Healthy control |
| SAMN33714291 | location_locality | Wuhan | R1 | 0.85 | biosample.attribute:geo_loc_name | China:Wuhan |
| SAMN33714291 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
| SAMN33714291 | subject_id | HC1 | R1 | 0.85 | sample.attr.host_subject_id | HC1 |
Sequencing
82 runs over 82 samples · mean 6.75 Gbp per run (median 6.72 Gbp, total 553.40 Gbp; 82 runs with a base count) · layout PAIRED 82 · platform ILLUMINA 82 · models Illumina HiSeq 2500 (82) · 91% of runs with a Sandpiper profile · first public 2024-04-28
Downloads
PRJNA943232.csv.gz (3.6 KB) · parquet (74.8 KB) — all 82 samples, every field with route and confidence · PRJNA943232_determinations.csv.gz (6.0 KB) — 738 evidence rows