Gut microbiome, sMAdCAM-1 in NSCLC, France & Canada
40 samples from advanced NSCLC patients treated with anti-PD-1/PD-L1 antibodies (with or without chemotherapy) in Montreal, Canada (25) and Paris, France (15), examining gut microbiome associations with serum sMAdCAM-1 at diagnosis; case-control design. machine-written summary
40 samples · 40 runs · CA, FR · Age unknown · 2023 · 2.71 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 320 sample values (age, collection date, country, latitude, location locality, location region, longitude, sex) |
| ✓ Abstract / description | 40 sample values (health condition detail) |
| – Full text | no open-access full text linked |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
No Sandpiper profile for this project's samples yet.
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 40 | 100% | ||||
| country | 40 | 100% | 40 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 40 | 100% | 40 | |||
| collection_date | 40 | 100% | 40 | |||
| detailed_location | 40 | 100% | ||||
| health_condition_detail | 40 | 100% | 40 | |||
| latitude | 40 | 100% | 40 | |||
| location_locality | 40 | 100% | 40 | |||
| location_region | 40 | 100% | 40 | |||
| longitude | 40 | 100% | 40 | |||
| sex | 40 | 100% | 40 |
Archive description
This project investigated gut microbiome associations with serum sMAdCAM-1 at diagnosis in two independent cohorts of patients with advanced NSCLC treated with anti-PD-1/PD-L1 antibodies with or without chemotherapy in France and Canada.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of elderly and adult by opus_adjudicated with confidence 0.85. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- host study.title · “NSCLC cancer patients”
- body site study.title · “associations with the gut microbiome”
- life stage sample.attr.host_age · “68 (n=22/40)”
- life stage sample.attr.host_age · “55 (n=18/40)”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN33737610 | age_at_collection_days | 26641.0 | R1 | 0.85 | sample.attr.host_age | 73 |
| SAMN33737610 | collection_date | 2019 | R1 | 0.90 | biosample.attribute:collection_date | 2019 |
| SAMN33737610 | country | FR | R1 | 0.90 | sample.attr.geo_loc_name | France:Paris |
| SAMN33737610 | health_condition_detail | mixed_case_control: NSCLC patients (serum sMAdCAM-1 associations studied) | R4 | 0.50 | study.description | patients with advanced NSCLC |
| SAMN33737610 | latitude | 48.7945 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79451203 N 2.34823081 E |
| SAMN33737610 | location_locality | Paris | R1 | 0.85 | biosample.attribute:geo_loc_name | France:Paris |
| SAMN33737610 | location_region | Ile-de-France | R1 | 0.60 | biosample.attribute:lat_lon | 48.79451203 N 2.34823081 E |
| SAMN33737610 | longitude | 2.3482 | R1 | 0.90 | biosample.attribute:lat_lon | 48.79451203 N 2.34823081 E |
| SAMN33737610 | sex | male | R1 | 0.90 | sample.attr.host_sex | male |
Sequencing
40 runs over 40 samples · mean 2.73 Gbp per run (median 2.71 Gbp, total 109.13 Gbp; 40 runs with a base count) · layout SINGLE 40 · platform ION_TORRENT 40 · models Ion Torrent Proton (40) · 0% of runs with a Sandpiper profile · first public 2023-03-17
Authors (0)
No author record.
Downloads
PRJNA944152.csv.gz (2.2 KB) · parquet (72.0 KB) — all 40 samples, every field with route and confidence · PRJNA944152_determinations.csv.gz (3.3 KB) — 360 evidence rows