Gut microbiome in aging adults and elderly, Kazakhstan
Cross-sectional study of 55 gut microbiome samples from Kazakhstan, comparing adult (n=31) and elderly (n=24) age groups to examine gut microbiota changes associated with aging and longevity. machine-written summary
55 samples · 55 runs · KZ · Adult · 2024 · 5.15 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 353 sample values (age, bmi, collection date, country, latitude, location region, longitude) |
| ✓ Abstract / description | 55 sample values (antibiotic exposure) |
| ○ Full text | read; no usable statement or table · PMC11008724, PMC12095471 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet · share metadata |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 39 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 55 | 100% | ||||
| country | 55 | 100% | 55 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 0 | 0% | ||||
| age_at_collection_days | 55 | 100% | 55 | |||
| antibiotic_exposure | 55 | 100% | 55 | |||
| bmi | 55 | 100% | 55 | |||
| collection_date | 55 | 100% | 55 | |||
| latitude | 55 | 100% | 55 | |||
| longitude | 55 | 100% | 55 | |||
| detailed_location | 23 | 42% | ||||
| location_region | 23 | 42% | 23 |
- The Trajectory of Successful Aging: Insights from Metagenome and Cytokine Profiling. 2024 PMID 38246133 PMC11008724 own_data
- Parity influences postpartum adaptations in the maternal gut microbiota. 2025 PMID 40399402 PMC12095471 own_data
- Examination of shared gut microbiome signatures in aging and Parkinson's disease. 2026 PMID 41907847 PMC13021664 unsure
Archive description
In healthy aging, centenarians are a successful model, exhibiting relatively low rates of various diseases and improved long-term health compared to older people. In the aging process, variation in the gut microbiome plays a key role, which is facilitated by the diet, genetics and lifestyle of older people. In this regard, the study of the gut microbiome / mycobiome of long-lived people may lead to an understanding of how, with increasing longevity, the gut microbiota adapts to changes and contributes to the maintenance of metabolic and immunological homeostasis of the body, as well as supports quality aging and increases the survival of the body.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of adult and elderly by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- body site study.title · “Immunoregulatory role of gut microbiome and mycobiome”
- body site study.description · “variation in the gut microbiome plays a”
- life stage external_curation.infant_catalog · “infant triage reason_code age_adult_only”
- life stage study.description · “In healthy aging, centenarians are a successful”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN35151998 | age_at_collection_days | 35756.7 | R1 | 0.85 | sample.attr.host_age | 98 |
| SAMN35151998 | antibiotic_exposure | no | R4 | 0.50 | paper.abstract | had not taken any antimicrobials, including probiotics |
| SAMN35151998 | bmi | 24.4 | R1 | 0.90 | sample.attr.host_body_mass_index | 24.4 |
| SAMN35151998 | collection_date | 2021-06-09 | R1 | 0.90 | biosample.attribute:collection_date | 2021-06-09 |
| SAMN35151998 | country | KZ | R1 | 0.90 | sample.attr.geo_loc_name | Kazakhstan |
| SAMN35151998 | latitude | 51.1000 | R1 | 0.90 | biosample.attribute:lat_lon | 51.10 N 71.26 E |
| SAMN35152044 | location_region | Astana Qalasy | R1 | 0.60 | biosample.attribute:lat_lon | 51.1605 N 71.4704 E |
| SAMN35151998 | longitude | 71.2600 | R1 | 0.90 | biosample.attribute:lat_lon | 51.10 N 71.26 E |
Sequencing
55 runs over 55 samples · mean 4.75 Gbp per run (median 5.15 Gbp, total 261.34 Gbp; 55 runs with a base count) · layout PAIRED 55 · platform ILLUMINA 55 · models Illumina NovaSeq 6000 (55) · 71% of runs with a Sandpiper profile · first public 2024-06-04
Authors (23)
Chulenbayeva L first · Ganzhula Y · Kozhakhmetov S · Jarmukhanov Z · Nurgaziyev M · Nurgozhina A · Muhanbetzhanov N · Sergazy S · Zhetkenev S · Borykbay Z · Tkachev V · Urazova S · Vinogradova E · Kushugulova A last · Mukhanbetzhanov N · Khassenbekova D · Tng TJW first · Vanan S · Tan EK · Zeng L · Goh WWB · Wong SH · Lim KL last
Help complete this project
2 of the 4 core fields are below 50% coverage: health_condition, subject_id. Share metadata
Downloads
PRJNA973824.csv.gz (2.7 KB) · parquet (72.6 KB) — all 55 samples, every field with route and confidence · PRJNA973824_determinations.csv.gz (3.8 KB) — 408 evidence rows