Infant gut microbiome in atopic dermatitis
13 infant gut microbiome samples from Seoul, South Korea, comparing infants with atopic dermatitis to healthy controls during the first six months of life, using a case-control design with multi-omics analysis. machine-written summary
13 samples · 13 runs · KR · Infant / toddler · 2023 · 3.57 Gbp / sample · cohort Seong 2025 South Korea AD infant cohort
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 26 sample values (country, subject id) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 26 sample values (age, location site) · PMC12122682 |
| – Supplementary tables | no supplementary tables available (or none open access) |
| – External resources | not covered by the external resources we ingest |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 11 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 13 | 100% | ||||
| country | 13 | 100% | 13 | |||
| health_condition | 0 | 0% | ||||
| subject_id | 13 | 100% | 13 | |||
| age_at_collection_days | 13 | 100% | 13 | |||
| detailed_location | 13 | 100% | ||||
| location_site | 13 | 100% | 13 |
- Integrated multi-omics reveals different host crosstalk of atopic dermatitis-enriched Bifidobacterium longum Strains. PMID 40442154 PMC12122682 curated
Archive description
The infant gut microbiome plays a critical role in human health and development. However, our understanding of its interactions with the human body and the implications for allergy development is currently limited. Our study investigated the gut microbiome of infants with atopic dermatitis (AD) and healthy controls during the first six months of life. We used multi-omics approaches to gain a deeper insight into microbiome-host interactions. We discovered distinct genetic signatures in Bifidobacterium strains present in infants with AD. These differences corresponded to changes in host transcripts. Our results underline an emerging hypothesis: strain-level differences may induce changes within the microbiome, affecting the host. This suggests that the gut-brain axis may influence the onset of AD.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of infant / toddler by deterministic_prior with confidence 0.90. Assay shotgun_dna.
- host external_curation.infant_catalog · “infant triage verdict include”
- body site study.title · “Bridge to the gut -brain axis with”
- body site study.description · “The infant gut microbiome plays a”
- life stage external_curation.infant_catalog · “infant triage verdict include (0-3 y scope)”
- life stage study.description · “The infant gut microbiome plays”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN35578392 | age_at_collection_days | 183 | R3 | 0.40 | paper.fulltext.methods | sixty 6-month-old infants |
| SAMN35578392 | country | KR | R1 | 0.90 | biosample_attr | South Korea: Seoul |
| SAMN35578392 | location_site | Asan Medical Center | R3 | 0.70 | paper.fulltext.methods | Childhood Asthma Atopy Center at Asan Medical Center |
| SAMN35578392 | subject_id | Sub2 | R1 | 0.85 | biosample_attr | Sub2 |
Sequencing
13 runs over 13 samples · mean 3.33 Gbp per run (median 3.57 Gbp, total 43.28 Gbp; 13 runs with a base count) · layout PAIRED 13 · platform ILLUMINA 13 · models Illumina HiSeq 2500 (13) · 85% of runs with a Sandpiper profile · first public 2023-06-12
Authors (12)
Seong HJ first · Park YM · Kim BS · Yoo HJ · Kim T · Yoon SM · Kim JH · Lee SY · Lee YK · Lee DW · Nam MH · Hong SJ last
Downloads
PRJNA979436.csv.gz (1.2 KB) · parquet (69.7 KB) — all 13 samples, every field with route and confidence · PRJNA979436_determinations.csv.gz (946 B) — 52 evidence rows