Gender differences in gut microbiota in Parkinson's disease
24 fecal metagenome samples from Parkinson's disease patients (13 male, 11 female) in Hangzhou, China, in a cross-sectional study examining gender-specific gut microbiota alterations and their correlation with brain function. machine-written summary
24 samples · 24 runs · CN · Age unknown · 2023 · 5.68 Gbp / sample
Checked this project's papers and archive records yourself? Mark it human-verified.
what each source gave
| ✓ Sequence archive | 192 sample values (collection date, country, health condition, health condition detail, latitude, location locality, longitude, sex) |
| ○ Abstract / description | read; no usable statement |
| ✓ Full text | 48 sample values (location site, subject id) · PMC10370496 |
| ○ Supplementary tables | files read; no table could be matched to the samples |
| ✓ External resources | 24 sample values (antibiotic exposure) · from BugSigDB |
| – User contribution | nothing uploaded yet |
| – Human verified | not yet checked by a person · I checked this project — verify it |
Genera, mean relative abundance over 21 profiled gut samples of this project (Sandpiper SingleM profiles, GTDB R232; low-depth and non-metagenome profiles left out).
| field | samples | coverage | R1 | R2 | R3 | R4 |
|---|---|---|---|---|---|---|
| age_category | 0 | 0% | ||||
| country | 24 | 100% | 24 | |||
| health_condition | 24 | 100% | 24 | |||
| subject_id | 24 | 100% | 24 | |||
| antibiotic_exposure | 24 | 100% | 24 | |||
| collection_date | 24 | 100% | 24 | |||
| detailed_location | 24 | 100% | ||||
| health_condition_detail | 24 | 100% | 24 | |||
| latitude | 24 | 100% | 24 | |||
| location_locality | 24 | 100% | 24 | |||
| location_site | 24 | 100% | 24 | |||
| longitude | 24 | 100% | 24 | |||
| sex | 24 | 100% | 24 |
- Exploring the alteration of gut microbiota and brain function in gender-specific Parkinson's disease based on metagenomic sequencing. 2023 PMID 37502423 PMC10370496 own_data
Archive description
Our study provides novel clinical evidence of the gender-specific relationship between gut microbiota alterations and brain function in PD patients, highlighting the critical role of the microbiota-gut-brain axis in gender differences in PD.
How this project entered the registry
Classified as human gut / stool shotgun DNA metagenome of age unknown by sonnet_x2 with confidence 0.65. Assay shotgun_dna.
- host run.host_tax_id · “9606”
- body site run.scientific_name · “human metagenome”
Evidence examples (one per field × route)
| sample | field | value | route | conf. | source | quote |
|---|---|---|---|---|---|---|
| SAMN35813273 | antibiotic_exposure | no | R2 | 0.60 | external.bugsigdb source | Antibiotics exclusion: 1 month |
| SAMN35813273 | collection_date | 2022-12 | R1 | 0.90 | biosample.attribute:collection_date | 2022-12 |
| SAMN35813273 | country | CN | R1 | 0.90 | sample.attr.geo_loc_name | China:HangZhou |
| SAMN35813273 | health_condition | neurological_psychiatric | R1 | 0.70 | sample.name_rule:alias | F_PD1 |
| SAMN35813273 | health_condition_detail | PD | R1 | 0.70 | sample.name_rule:alias | F_PD1 |
| SAMN35813273 | latitude | 30.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 30 N 120 E |
| SAMN35813273 | location_locality | Hangzhou | R1 | 0.85 | biosample.attribute:geo_loc_name | China:HangZhou |
| SAMN35813273 | location_site | First People's Hospital of Huai'an City, Department of Neurology | R3 | 0.70 | paper.fulltext.methods | Department of Neurology of the First People’s Hospital of Huai’an City |
| SAMN35813273 | longitude | 120.0000 | R1 | 0.90 | biosample.attribute:lat_lon | 30 N 120 E |
| SAMN35813273 | sex | female | R1 | 0.70 | sample.name_rule:alias | F_PD1 |
| SAMN35813273 | subject_id | SAMN35813273 | R3 | 0.75 | design.one_sample_per_subject:fulltext | One clinical fecal sample per patient was collected. |
Sequencing
24 runs over 24 samples · mean 6.00 Gbp per run (median 5.68 Gbp, total 143.93 Gbp; 24 runs with a base count) · layout SINGLE 24 · platform ILLUMINA 24 · models Illumina NovaSeq 6000 (24) · 88% of runs with a Sandpiper profile · first public 2023-07-03
Authors (10)
Zhang M first · Zhai Z · Yang B · He L · Wang J · Dai W · Xue L · Yang X · Feng Y · Wang H last
Downloads
PRJNA985875.csv.gz (1.7 KB) · parquet (71.8 KB) — all 24 samples, every field with route and confidence · PRJNA985875_determinations.csv.gz (3.1 KB) — 264 evidence rows